{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Falfan-Valencia R"],"funding":["Consejo Nacional de Ciencia y Tecnología"],"pagination":["3174868"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5845504"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2018"],"pubmed_abstract":["<h4>Background</h4>The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement of genetic factors. There are scarce data available on classical HLA class I association with the influenza A H1N1/09 pandemic.<h4>Methods</h4>We analyzed the frequency of classical HLA class I alleles and haplotypes in A H1N1/09 influenza in a case-control study including 138 influenza patients (INF-P) and 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. HLA class I typing was performed by high-resolution sequence-based typing method.<h4>Results</h4>Our analysis revealed higher frequency of C∗07:02:01, B∗39:06:02, C∗03:02:01, B∗44:03:01, B∗51:01:05, and B∗73:01 (<i>p</i> < 0.05; OR = 1.84-9.98) and of two haplotypes-A∗68:01:02-C∗07:02:01 (<i"],"journal":["Journal of immunology research"],"pubmed_title":["An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study."],"pmcid":["PMC5845504"],"funding_grant_id":["SALUD-2009-126731","SALUD-2009-C02-126699"],"pubmed_authors":["Falfan-Valencia R","Bautista-Felix NE","Perez-Rubio G","Resendiz-Hernandez JM","Ramirez-Venegas A","Narayanankutty A","Castillejos-Lopez MDJ","Vargas-Alarcon G","Hernandez A","Nava-Quiroz KJ"],"additional_accession":[]},"is_claimable":false,"name":"An Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study.","description":"<h4>Background</h4>The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement of genetic factors. There are scarce data available on classical HLA class I association with the influenza A H1N1/09 pandemic.<h4>Methods</h4>We analyzed the frequency of classical HLA class I alleles and haplotypes in A H1N1/09 influenza in a case-control study including 138 influenza patients (INF-P) and 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. HLA class I typing was performed by high-resolution sequence-based typing method.<h4>Results</h4>Our analysis revealed higher frequency of C∗07:02:01, B∗39:06:02, C∗03:02:01, B∗44:03:01, B∗51:01:05, and B∗73:01 (<i>p</i> < 0.05; OR = 1.84-9.98) and of two haplotypes-A∗68:01:02-C∗07:02:01 (<i","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2026-05-06T03:58:46.382Z","creation":"2026-04-27T03:07:59.298Z"},"accession":"S-EPMC5845504","cross_references":{"pubmed":["29682588"],"doi":["10.1155/2018/3174868"]}}