biostudies-literatureFalfan-Valencia RConsejo Nacional de Ciencia y Tecnología3174868https://www.ebi.ac.uk/biostudies/studies/S-EPMC5845504biostudies-literatureUnknown2018<h4>Background</h4>The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement of genetic factors. There are scarce data available on classical HLA class I association with the influenza A H1N1/09 pandemic.<h4>Methods</h4>We analyzed the frequency of classical HLA class I alleles and haplotypes in A H1N1/09 influenza in a case-control study including 138 influenza patients (INF-P) and 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. HLA class I typing was performed by high-resolution sequence-based typing method.<h4>Results</h4>Our analysis revealed higher frequency of C∗07:02:01, B∗39:06:02, C∗03:02:01, B∗44:03:01, B∗51:01:05, and B∗73:01 (<i>p</i> < 0.05; OR = 1.84-9.98) and of two haplotypes-A∗68:01:02-C∗07:02:01 (<iJournal of immunology researchAn Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study.PMC5845504SALUD-2009-126731SALUD-2009-C02-126699Falfan-Valencia RBautista-Felix NEPerez-Rubio GResendiz-Hernandez JMRamirez-Venegas ANarayanankutty ACastillejos-Lopez MDJVargas-Alarcon GHernandez ANava-Quiroz KJfalseAn Increased Frequency in HLA Class I Alleles and Haplotypes Suggests Genetic Susceptibility to Influenza A (H1N1) 2009 Pandemic: A Case-Control Study.<h4>Background</h4>The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement of genetic factors. There are scarce data available on classical HLA class I association with the influenza A H1N1/09 pandemic.<h4>Methods</h4>We analyzed the frequency of classical HLA class I alleles and haplotypes in A H1N1/09 influenza in a case-control study including 138 influenza patients (INF-P) and 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. HLA class I typing was performed by high-resolution sequence-based typing method.<h4>Results</h4>Our analysis revealed higher frequency of C∗07:02:01, B∗39:06:02, C∗03:02:01, B∗44:03:01, B∗51:01:05, and B∗73:01 (<i>p</i> < 0.05; OR = 1.84-9.98) and of two haplotypes-A∗68:01:02-C∗07:02:01 (<i2018-01-01T00:00:00Z20182026-05-06T03:58:46.382Z2026-04-27T03:07:59.298ZS-EPMC58455042968258810.1155/2018/3174868