biostudies-literature00390Unknown9(16)Jang BIn advanced cancer therapy, the combinational therapeutic effect of photothermal therapy (PTT) using near-infrared (NIR) light-responsive nanoparticles (NPs) and anti-cancer drug delivery-mediated chemotherapy has been widely applied. In the present study, using a facile, low-cost, and solution-based method, we developed and synthesized fucoidan, a natural polymer isolated from seaweed that has demonstrated anti-cancer effect, and coated NPs with it as an ideal candidate in chemo-photothermal therapy against cancer cells. Fucoidan-coated copper sulfide nanoparticles (F-CuS) act not only as a nanocarrier to enhance the intracellular delivery of fucoidan but also as a photothermal agent to effectively ablate different cancer cells (e.g., HeLa, A549, and K562), both <i>in vitro</i> and <i>in vivo</i>, with the induction of apoptosis under 808 nm diode laser irradiation. These results point to the potential usage of F-CuS in treating human cancer.Oncotarget12649-12661https://www.ebi.ac.uk/biostudies/studies/S-EPMC5849162biostudies-literatureFucoidan-coated CuS nanoparticles for chemo-and photothermal therapy against cancer.PMC5849162Xu LSong KJang BLee KDKwak MOh JJin JOMoorthy MSManivasagan P39falseFucoidan-coated CuS nanoparticles for chemo-and photothermal therapy against cancer.In advanced cancer therapy, the combinational therapeutic effect of photothermal therapy (PTT) using near-infrared (NIR) light-responsive nanoparticles (NPs) and anti-cancer drug delivery-mediated chemotherapy has been widely applied. In the present study, using a facile, low-cost, and solution-based method, we developed and synthesized fucoidan, a natural polymer isolated from seaweed that has demonstrated anti-cancer effect, and coated NPs with it as an ideal candidate in chemo-photothermal therapy against cancer cells. Fucoidan-coated copper sulfide nanoparticles (F-CuS) act not only as a nanocarrier to enhance the intracellular delivery of fucoidan but also as a photothermal agent to effectively ablate different cancer cells (e.g., HeLa, A549, and K562), both <i>in vitro</i> and <i>in vivo</i>, with the induction of apoptosis under 808 nm diode laser irradiation. These results point to the potential usage of F-CuS in treating human cancer.2018-01-01T00:00:00Z2018 Feb2024-11-06T16:46:06.263Z2019-03-26T23:22:54ZS-EPMC58491622956009810.18632/oncotarget.23898