{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Chaurand P"],"pubmed_abstract":["In this methodological study, we demonstrated the relevance of 3D imaging performed at various scales for the ex vivo detection and location of cerium oxide nanomaterials (CeO2-NMs) in mouse lung. X-ray micro-computed tomography (micro-CT) with a voxel size from 14 µm to 1 µm (micro-CT) was combined with X-ray nano-computed tomography with a voxel size of 63 nm (nano-CT). An optimized protocol was proposed to facilitate the sample preparation, to minimize the experimental artifacts and to optimize the contrast of soft tissues exposed to metal-based nanomaterials (NMs). 3D imaging of the NMs biodistribution in lung tissues was consolidated by combining a vast variety of techniques in a correlative approach: histological observations, 2D chemical mapping and speciation analysis were performe"],"journal":["Scientific reports"],"pagination":["4408"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5849692"],"repository":["biostudies-literature"],"pubmed_title":["Multi-scale X-ray computed tomography to detect and localize metal-based nanomaterials in lung tissues of in vivo exposed mice."],"pmcid":["PMC5849692"],"pubmed_authors":["Auffan M","Borschneck D","Collin B","Kieffer I","Rose J","Perrin J","Lanone S","Paul E","Chaurand P","Liu W","Levard C"],"additional_accession":[]},"is_claimable":false,"name":"Multi-scale X-ray computed tomography to detect and localize metal-based nanomaterials in lung tissues of in vivo exposed mice.","description":"In this methodological study, we demonstrated the relevance of 3D imaging performed at various scales for the ex vivo detection and location of cerium oxide nanomaterials (CeO2-NMs) in mouse lung. X-ray micro-computed tomography (micro-CT) with a voxel size from 14 µm to 1 µm (micro-CT) was combined with X-ray nano-computed tomography with a voxel size of 63 nm (nano-CT). An optimized protocol was proposed to facilitate the sample preparation, to minimize the experimental artifacts and to optimize the contrast of soft tissues exposed to metal-based nanomaterials (NMs). 3D imaging of the NMs biodistribution in lung tissues was consolidated by combining a vast variety of techniques in a correlative approach: histological observations, 2D chemical mapping and speciation analysis were performe","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2025-04-18T20:16:42.564Z","creation":"2019-03-26T23:22:55Z"},"accession":"S-EPMC5849692","cross_references":{"pubmed":["29535369"],"doi":["10.1038/s41598-018-21862-4"]}}