{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yacoub S"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["1453-1461"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5850435"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["65(9)"],"pubmed_abstract":["<h4>Background</h4>Dengue can cause increased vascular permeability that may lead to hypovolemic shock. Endothelial dysfunction may underlie this; however, the association of endothelial nitric oxide (NO) pathways with disease severity is unknown.<h4>Methods</h4>We performed a prospective observational study in 2 Vietnamese hospitals, assessing patients presenting early (<72 hours of fever) and patients hospitalized with warning signs or severe dengue. The reactive hyperemic index (RHI), which measures endothelium-dependent vasodilation and is a surrogate marker of endothelial function and NO bioavailability, was evaluated using peripheral artery tonometry (EndoPAT), and plasma levels of l-arginine, arginase-1, and asymmetric dimethylarginine were measured at serial time-points. The main o"],"journal":["Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"],"pubmed_title":["Endothelial Nitric Oxide Pathways in the Pathophysiology of Dengue: A Prospective Observational Study."],"pmcid":["PMC5850435"],"funding_grant_id":["G0801508","100562/Z/12/Z","G0600000","NF-SI-0507-10303"],"pubmed_authors":["Yeo TW","Screaton G","Simmons C","Le DHT","Nguyen Ho HH","Van NT","Lien LT","Wills B","Yacoub S","Dong Thi HT","Ha QNT","Lam PK","Culshaw A","Huynh TT","Mongkolspaya J","Wertheim H"],"additional_accession":[]},"is_claimable":false,"name":"Endothelial Nitric Oxide Pathways in the Pathophysiology of Dengue: A Prospective Observational Study.","description":"<h4>Background</h4>Dengue can cause increased vascular permeability that may lead to hypovolemic shock. Endothelial dysfunction may underlie this; however, the association of endothelial nitric oxide (NO) pathways with disease severity is unknown.<h4>Methods</h4>We performed a prospective observational study in 2 Vietnamese hospitals, assessing patients presenting early (<72 hours of fever) and patients hospitalized with warning signs or severe dengue. The reactive hyperemic index (RHI), which measures endothelium-dependent vasodilation and is a surrogate marker of endothelial function and NO bioavailability, was evaluated using peripheral artery tonometry (EndoPAT), and plasma levels of l-arginine, arginase-1, and asymmetric dimethylarginine were measured at serial time-points. The main o","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2025-04-18T20:16:37.485Z","creation":"2019-03-26T23:22:56Z"},"accession":"S-EPMC5850435","cross_references":{"pubmed":["28673038"],"doi":["10.1093/cid/cix567"]}}