biostudies-literature00450Hofstra JLCalifornia Institute of TechnologyAmerican Cancer SocietyNational Institute of General Medical SciencesNIGMS NIH HHSDivision of Graduate Education139-142https://www.ebi.ac.uk/biostudies/studies/S-EPMC5851001biostudies-literatureUnknown140(1)An asymmetric Ni-catalyzed reductive cross-coupling has been developed to prepare enantioenriched allylic silanes. This enantioselective reductive alkenylation proceeds under mild conditions and exhibits good functional group tolerance. The chiral allylic silanes prepared here undergo a variety of stereospecific transformations, including intramolecular Hosomi-Sakurai reactions, to set vicinal stereogenic centers with excellent transfer of chirality.Journal of the American Chemical SocietySynthesis of Enantioenriched Allylic Silanes via Nickel-Catalyzed Reductive Cross-Coupling.PMC5851001R01 GM111805DGE-1144469R35 GM118191GM111805-01R35GM118191-01Reisman SECherney AHOrdner CMHofstra JL45falseSynthesis of Enantioenriched Allylic Silanes via Nickel-Catalyzed Reductive Cross-Coupling.An asymmetric Ni-catalyzed reductive cross-coupling has been developed to prepare enantioenriched allylic silanes. This enantioselective reductive alkenylation proceeds under mild conditions and exhibits good functional group tolerance. The chiral allylic silanes prepared here undergo a variety of stereospecific transformations, including intramolecular Hosomi-Sakurai reactions, to set vicinal stereogenic centers with excellent transfer of chirality.2018-01-01T00:00:00Z2018 Jan2024-11-13T17:12:00.86Z2019-03-26T22:35:28ZS-EPMC58510012920224310.1021/jacs.7b11707