{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma X"],"funding":["European Hematology Association","NCI NIH HHS"],"pagination":["371-376"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5854542"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["555(7696)"],"pubmed_abstract":["Analysis of molecular aberrations across multiple cancer types, known as pan-cancer analysis, identifies commonalities and differences in key biological processes that are dysregulated in cancer cells from diverse lineages. Pan-cancer analyses have been performed for adult but not paediatric cancers, which commonly occur in developing mesodermic rather than adult epithelial tissues. Here we present a pan-cancer study of somatic alterations, including single nucleotide variants, small insertions or deletions, structural variations, copy number alterations, gene fusions and internal tandem duplications in 1,699 paediatric leukaemias and solid tumours across six histotypes, with whole-genome, whole-exome and transcriptome sequencing data processed under a uniform analytical framework. We repo"],"journal":["Nature"],"pubmed_title":["Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours."],"pmcid":["PMC5854542"],"funding_grant_id":["U10 CA098543","TRTH75","P30 CA021765","HHSN261200800001E","CA21765"],"pubmed_authors":["Maris JM","Ries RE","Zhang J","Hermida LC","Meltzer PS","Ma X","Davis S","Dong L","Edmonson MN","Liu Y","Diskin SJ","Hunger SP","Gerhard DS","Gawad C","Perlman EJ","Chen X","Gonzalez-Pena V","Wang Z","Wilkinson MR","Guidry Auvil JM","Alexandrov LB","Easton J","Meshinchi S","Zhou X","Pounds S","Li Y","Huether R","Cao X","Rusch MC","Smith MA","Sioson E","Lau CC"],"additional_accession":[]},"is_claimable":false,"name":"Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours.","description":"Analysis of molecular aberrations across multiple cancer types, known as pan-cancer analysis, identifies commonalities and differences in key biological processes that are dysregulated in cancer cells from diverse lineages. Pan-cancer analyses have been performed for adult but not paediatric cancers, which commonly occur in developing mesodermic rather than adult epithelial tissues. Here we present a pan-cancer study of somatic alterations, including single nucleotide variants, small insertions or deletions, structural variations, copy number alterations, gene fusions and internal tandem duplications in 1,699 paediatric leukaemias and solid tumours across six histotypes, with whole-genome, whole-exome and transcriptome sequencing data processed under a uniform analytical framework. We repo","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2026-04-30T10:45:09.169Z","creation":"2019-03-26T23:52:33Z"},"accession":"S-EPMC5854542","cross_references":{"pubmed":["29489755"],"doi":["10.1038/nature25795"]}}