{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen H"],"funding":["NCATS NIH HHS","Swiss National Science Foundation","NIDDK NIH HHS","NCRR NIH HHS","NIA NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NCI NIH HHS","NIAMS NIH HHS"],"pagination":["391-401"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5854957"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(3)"],"pubmed_abstract":["Obstructive sleep apnea (OSA) is a common heritable disorder displaying marked sexual dimorphism in disease prevalence and progression. Previous genetic association studies have identified a few genetic loci associated with OSA and related quantitative traits, but they have only focused on single ethnic groups, and a large proportion of the heritability remains unexplained. The apnea-hypopnea index (AHI) is a commonly used quantitative measure characterizing OSA severity. Because OSA differs by sex, and the pathophysiology of obstructive events differ in rapid eye movement (REM) and non-REM (NREM) sleep, we hypothesized that additional genetic association signals would be identified by analyzing the NREM/REM-specific AHI and by conducting sex-specific analyses in multiethnic samples. We pe"],"journal":["American journal of respiratory cell and molecular biology"],"pubmed_title":["Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men."],"pmcid":["PMC5854957"],"funding_grant_id":["U01 AG042139","105993","HHSN268201100009I","R01 AG023629","HHSN268201100009C","KL2 TR000461","N01HC25195","R01 HL102830","T32 HL007901","UL1 TR000124","R01 HL120393","U01 AG042145","UL1 TR000128","HHSN268200800007C","U01 AG042143","U01 AG042140","RC2 AR058973","P30 DK063491","R01 AR051124","U01 HL080295","R01 DK105072","P30 DK020595","N01HC65236","N01HC65237","N01HC65234","N01HC65235","N01HC65233","R01 HL087652","U01 AG042124","U01 DK085501","R01 HL071194","U01 AG027810","N02HL64278","R01 DK073541","R01 HL103612","R01 HL105756","U01 HL130114","UL1 TR001881","UL1 TR000439","N01HC95159","HHSN268201100005C","R01 AI085014","U01 AR066160","R01 HL062252","KL2 RR024990","R01 HL085251","HHSN268201100005I","HHSN268201100005G","K01 HL135405","UL1 TR000040","R01 HL070841","U01 HL053941","R01 HL070842","HHSN268201100006C","N01HC85079","R01 HL070838","HHSN268201100010C","R01 HL070837","R01 HL070839","HHSN268201100011I","N01HC85081","N01HC85082","N01HC85080","HHSN268201200036C","HHSN268201100007C","N01HC85086","N01HC85083","P50 HL056984","R21 AG056952","R01 HL070847","R01 HL046380","HHSN268201100011C","R01 DK107859","R01 HL070848","HHSN268201100007I","P01 CA134294","R35 CA197449","HHSN268201500003C","HHSN268201300005C","N01HC95160","N01HC95161","UL1 TR001079","N01HC95162","U01 AG042168","N01HC95163","N01HC95164","N01HC95165","N01HC95166","N01HC95167","R01 HL113338","N01HC95168","N01HC95169","N01HC55222","R35 HL135818","HHSN268201100008C","HHSN268201500003I","HHSN268201100008I","HHSN268201100012C"],"pubmed_authors":["Ramos AR","Evans DS","Rotter JI","Wang C","Rice K","Zee PC","Hanis CL","Larkin EK","Lin X","Wang H","Papanicolaou GJ","Sunyaev SR","Gleason KJ","Sands SA","Warby SC","Liang J","Patel SR","Tranah GJ","Ewert R","Palmer LJ","Bell GI","Chen H","Arens R","Below JE","Gharib SA","Loredo JS","Redline S","Sul JH","Mukherjee S","Tafti M","Haba-Rubio J","Frazier-Wood AC","Ancoli-Israel S","Kutalik Z","Saxena R","Lane JM","Hagen EW","Azarbarzin A","Chun S","Shah NA","Conomos MP","Sofer T","Hillman DR","Post WS","Peppard PE","Gottlieb DJ","Johnson WC","Lee SK","Taylor KD","Bjonnes AC","Stilp AM","Stone KL","Laurie CC","Wellman DA","Shin C","Thornton TA","Cade BE","Penzel T","Heinzer R","Teumer A","Zhu X","Stubbe B"],"additional_accession":[]},"is_claimable":false,"name":"Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.","description":"Obstructive sleep apnea (OSA) is a common heritable disorder displaying marked sexual dimorphism in disease prevalence and progression. Previous genetic association studies have identified a few genetic loci associated with OSA and related quantitative traits, but they have only focused on single ethnic groups, and a large proportion of the heritability remains unexplained. The apnea-hypopnea index (AHI) is a commonly used quantitative measure characterizing OSA severity. Because OSA differs by sex, and the pathophysiology of obstructive events differ in rapid eye movement (REM) and non-REM (NREM) sleep, we hypothesized that additional genetic association signals would be identified by analyzing the NREM/REM-specific AHI and by conducting sex-specific analyses in multiethnic samples. We pe","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2025-04-26T00:18:38.339Z","creation":"2019-06-06T19:08:37Z"},"accession":"S-EPMC5854957","cross_references":{"pubmed":["29077507"],"doi":["10.1165/rcmb.2017-0237OC","10.1165/rcmb.2017-0237oc"]}}