biostudies-literatureChen HNCATS NIH HHSSwiss National Science FoundationNIDDK NIH HHSNCRR NIH HHSNIA NIH HHSNIAID NIH HHSNHLBI NIH HHSNCI NIH HHSNIAMS NIH HHS391-401https://www.ebi.ac.uk/biostudies/studies/S-EPMC5854957biostudies-literatureUnknown58(3)Obstructive sleep apnea (OSA) is a common heritable disorder displaying marked sexual dimorphism in disease prevalence and progression. Previous genetic association studies have identified a few genetic loci associated with OSA and related quantitative traits, but they have only focused on single ethnic groups, and a large proportion of the heritability remains unexplained. The apnea-hypopnea index (AHI) is a commonly used quantitative measure characterizing OSA severity. Because OSA differs by sex, and the pathophysiology of obstructive events differ in rapid eye movement (REM) and non-REM (NREM) sleep, we hypothesized that additional genetic association signals would be identified by analyzing the NREM/REM-specific AHI and by conducting sex-specific analyses in multiethnic samples. We peAmerican journal of respiratory cell and molecular biologyMultiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.PMC5854957U01 AG042139105993HHSN268201100009IR01 AG023629HHSN268201100009CKL2 TR000461N01HC25195R01 HL102830T32 HL007901UL1 TR000124R01 HL120393U01 AG042145UL1 TR000128HHSN268200800007CU01 AG042143U01 AG042140RC2 AR058973P30 DK063491R01 AR051124U01 HL080295R01 DK105072P30 DK020595N01HC65236N01HC65237N01HC65234N01HC65235N01HC65233R01 HL087652U01 AG042124U01 DK085501R01 HL071194U01 AG027810N02HL64278R01 DK073541R01 HL103612R01 HL105756U01 HL130114UL1 TR001881UL1 TR000439N01HC95159HHSN268201100005CR01 AI085014U01 AR066160R01 HL062252KL2 RR024990R01 HL085251HHSN268201100005IHHSN268201100005GK01 HL135405UL1 TR000040R01 HL070841U01 HL053941R01 HL070842HHSN268201100006CN01HC85079R01 HL070838HHSN268201100010CR01 HL070837R01 HL070839HHSN268201100011IN01HC85081N01HC85082N01HC85080HHSN268201200036CHHSN268201100007CN01HC85086N01HC85083P50 HL056984R21 AG056952R01 HL070847R01 HL046380HHSN268201100011CR01 DK107859R01 HL070848HHSN268201100007IP01 CA134294R35 CA197449HHSN268201500003CHHSN268201300005CN01HC95160N01HC95161UL1 TR001079N01HC95162U01 AG042168N01HC95163N01HC95164N01HC95165N01HC95166N01HC95167R01 HL113338N01HC95168N01HC95169N01HC55222R35 HL135818HHSN268201100008CHHSN268201500003IHHSN268201100008IHHSN268201100012CRamos AREvans DSRotter JIWang CRice KZee PCHanis CLLarkin EKLin XWang HPapanicolaou GJSunyaev SRGleason KJSands SAWarby SCLiang JPatel SRTranah GJEwert RPalmer LJBell GIChen HArens RBelow JEGharib SALoredo JSRedline SSul JHMukherjee STafti MHaba-Rubio JFrazier-Wood ACAncoli-Israel SKutalik ZSaxena RLane JMHagen EWAzarbarzin AChun SShah NAConomos MPSofer THillman DRPost WSPeppard PEGottlieb DJJohnson WCLee SKTaylor KDBjonnes ACStilp AMStone KLLaurie CCWellman DAShin CThornton TACade BEPenzel THeinzer RTeumer AZhu XStubbe BfalseMultiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.Obstructive sleep apnea (OSA) is a common heritable disorder displaying marked sexual dimorphism in disease prevalence and progression. Previous genetic association studies have identified a few genetic loci associated with OSA and related quantitative traits, but they have only focused on single ethnic groups, and a large proportion of the heritability remains unexplained. The apnea-hypopnea index (AHI) is a commonly used quantitative measure characterizing OSA severity. Because OSA differs by sex, and the pathophysiology of obstructive events differ in rapid eye movement (REM) and non-REM (NREM) sleep, we hypothesized that additional genetic association signals would be identified by analyzing the NREM/REM-specific AHI and by conducting sex-specific analyses in multiethnic samples. We pe2018-01-01T00:00:00Z2018 Mar2025-04-26T00:18:38.339Z2019-06-06T19:08:37ZS-EPMC58549572907750710.1165/rcmb.2017-0237OC10.1165/rcmb.2017-0237oc