biostudies-literatureUnknown8(3)Peters SAE<h4>Objective</h4>To assess the relationship between risk factor clusters and cardiovascular disease (CVD) incidence in Asian and Caucasian populations and to estimate the burden of CVD attributable to each cluster.<h4>Setting</h4>Asia Pacific Cohort Studies Collaboration.<h4>Participants</h4>Individual participant data from 34 population-based cohorts, involving 314 024 participants without a history of CVD at baseline.<h4>Outcome measures</h4>Clusters were 11 possible combinations of four individual risk factors (current smoking, overweight, blood pressure (BP) and total cholesterol). Cox regression models were used to obtain adjusted HRs and 95% CIs for CVD associated with individual risk factors and risk factor clusters. Population-attributable fractions (PAFs) were calculated.<h4>ResuBMJ opene019335https://www.ebi.ac.uk/biostudies/studies/S-EPMC5855160biostudies-literatureClustering of risk factors and the risk of incident cardiovascular disease in Asian and Caucasian populations: results from the Asia Pacific Cohort Studies Collaboration.PMC5855160Luszcz MLiu LSKagaya MMacmahon SSuh IHirakawa YKnuiman MWZhou BFChen LQTamakoshi AZhang HYOkayama HJamrozik KNakachi KHata JImai YWang XHozawa AKita YHughes KWoo JTang ZPeters SAETanaka HLam THHeng DLi YHUeshima HWu XGAsia Pacific Cohort Studies CollaborationNinomiya THuxley RMaegawa HSritara PHe YYao CHYao SXHo SNorton RBroadhurst RChristensen HMatsutani YHo SCShan GLHuang MSLee JGu DFShimamoto KKim ISBots MLYu XHJee SHR Choudhury SHashimoto TZhou BPan WHGiles GGXie JXJiang CQNorman POhkubo TChen ZMChew SKWelborn TAZhou JVaartjes INozaki ARodgers AAoki NWu ZSHobbs MSaitoh SWoodward MJackson RWhitlock GDuan XFAmeratunga SWu ZLH Pan WLi SCHoribe HKnuiman MFang XHong ZImai ADYKim HCFuh JLYang QDLi ZZSakata KH Fang XfalseClustering of risk factors and the risk of incident cardiovascular disease in Asian and Caucasian populations: results from the Asia Pacific Cohort Studies Collaboration.<h4>Objective</h4>To assess the relationship between risk factor clusters and cardiovascular disease (CVD) incidence in Asian and Caucasian populations and to estimate the burden of CVD attributable to each cluster.<h4>Setting</h4>Asia Pacific Cohort Studies Collaboration.<h4>Participants</h4>Individual participant data from 34 population-based cohorts, involving 314 024 participants without a history of CVD at baseline.<h4>Outcome measures</h4>Clusters were 11 possible combinations of four individual risk factors (current smoking, overweight, blood pressure (BP) and total cholesterol). Cox regression models were used to obtain adjusted HRs and 95% CIs for CVD associated with individual risk factors and risk factor clusters. Population-attributable fractions (PAFs) were calculated.<h4>Resu2018-01-01T00:00:00Z2018 Mar2025-04-04T09:06:17.311Z2019-03-26T22:47:16ZS-EPMC58551602951101310.1136/bmjopen-2017-019335