{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun Y"],"funding":["Guangdong Medical Research Foundation","National Natural Science Foundation of China"],"pagination":["E472"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5855694"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(2)"],"pubmed_abstract":["As the most common cause of cancer death in women, the pathogenesis of breast cancer still remains unclear. Here, we reported a long non-coding RNA (lncRNA), HOTTIP (HOXA transcript at the distal tip), that may play an important role in the pathogenesis of breast cancer. Using gain-and-loss-of experiments in vitro and in vivo, we observed the marked upregulation of HOTTIP/HOXA11 in the breast cancer cell line, MCF-7, and the downregulation of HOTTIP or HOXA11, which might inhibit cell proliferation and migration but promote cell apoptosis in breast cancer MCF-7 cells. In addition, by further rescue experiments with HOXA11 overexpression, we uncovered a novel potential regulatory mechanism between HOTTIP and one of its physical HOXA clusters, HOXA11. Hence, HOTTIP may mediate, at least part"],"journal":["International journal of molecular sciences"],"pubmed_title":["LncRNA HOTTIP-Mediated HOXA11 Expression Promotes Cell Growth, Migration and Inhibits Cell Apoptosis in Breast Cancer."],"pmcid":["PMC5855694"],"funding_grant_id":["A2017330","81702285, 81472275"],"pubmed_authors":["Zeng C","Gan S","Li H","Li R","Zhu W","Sun Y","Cheng Y","Chen D"],"additional_accession":[]},"is_claimable":false,"name":"LncRNA HOTTIP-Mediated HOXA11 Expression Promotes Cell Growth, Migration and Inhibits Cell Apoptosis in Breast Cancer.","description":"As the most common cause of cancer death in women, the pathogenesis of breast cancer still remains unclear. Here, we reported a long non-coding RNA (lncRNA), HOTTIP (HOXA transcript at the distal tip), that may play an important role in the pathogenesis of breast cancer. Using gain-and-loss-of experiments in vitro and in vivo, we observed the marked upregulation of HOTTIP/HOXA11 in the breast cancer cell line, MCF-7, and the downregulation of HOTTIP or HOXA11, which might inhibit cell proliferation and migration but promote cell apoptosis in breast cancer MCF-7 cells. In addition, by further rescue experiments with HOXA11 overexpression, we uncovered a novel potential regulatory mechanism between HOTTIP and one of its physical HOXA clusters, HOXA11. Hence, HOTTIP may mediate, at least part","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Feb","modification":"2025-04-04T09:06:29.452Z","creation":"2019-03-26T23:23:10Z"},"accession":"S-EPMC5855694","cross_references":{"pubmed":["29415429"],"doi":["10.3390/ijms19020472"]}}