{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":39,"searchCount":0},"additional":{"omics_type":["Unknown"],"volume":["8(12)"],"submitter":["Wei W"],"pubmed_abstract":["Natural availability of carbonyl groups offers reductive carbonyl coupling tremendous synthetic potential for efficient olefin synthesis, yet the catalytic carbonyl cross-coupling remains largely elusive. We report herein such a reaction, mediated by hydrazine under ruthenium(ii) catalysis. This method enables facile and selective cross-couplings of two unsymmetrical carbonyl compounds in either an intermolecular or intramolecular fashion. Moreover, this chemistry accommodates a variety of substrates, proceeds under mild reaction conditions with good functional group tolerance, and generates stoichiometric benign byproducts. Importantly, the coexistence of KO <sup><i>t</i></sup> Bu and bidentate phosphine dmpe is vital to this transformation."],"journal":["Chemical science"],"pagination":["8193-8197"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5855968"],"repository":["biostudies-literature"],"pubmed_title":["Ruthenium(ii)-catalyzed olefination <i>via</i> carbonyl reductive cross-coupling."],"pmcid":["PMC5855968"],"pubmed_authors":["Yang X","Li C","Li CJ","Dai XJ","Wei W","Wang H"],"view_count":["39"],"additional_accession":[]},"is_claimable":false,"name":"Ruthenium(ii)-catalyzed olefination <i>via</i> carbonyl reductive cross-coupling.","description":"Natural availability of carbonyl groups offers reductive carbonyl coupling tremendous synthetic potential for efficient olefin synthesis, yet the catalytic carbonyl cross-coupling remains largely elusive. We report herein such a reaction, mediated by hydrazine under ruthenium(ii) catalysis. This method enables facile and selective cross-couplings of two unsymmetrical carbonyl compounds in either an intermolecular or intramolecular fashion. Moreover, this chemistry accommodates a variety of substrates, proceeds under mild reaction conditions with good functional group tolerance, and generates stoichiometric benign byproducts. Importantly, the coexistence of KO <sup><i>t</i></sup> Bu and bidentate phosphine dmpe is vital to this transformation.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Dec","modification":"2022-02-09T10:42:56.907Z","creation":"2019-03-26T23:23:12Z"},"accession":"S-EPMC5855968","cross_references":{"pubmed":["29568466"],"doi":["10.1039/c7sc04207h"]}}