biostudies-literatureLiu KNSFCNHLBI NIH HHSNHMRCNLM NIH HHSNCI NIH HHSNational Institutes of HealthNIAMS NIH HHSNIGMS NIH HHS2622-2630https://www.ebi.ac.uk/biostudies/studies/S-EPMC5860060biostudies-literatureUnknown33(17)<h4>Motivation</h4>Long non-coding RNAs (lncRNAs) have been implicated in the regulation of diverse biological functions. The number of newly identified lncRNAs has increased dramatically in recent years but their expression and function have not yet been described from most diseases. To elucidate lncRNA function in human disease, we have developed a novel network based method (NLCFA) integrating correlations between lncRNA, protein coding genes and noncoding miRNAs. We have also integrated target gene associations and protein-protein interactions and designed our model to provide information on the combined influence of mRNAs, lncRNAs and miRNAs on cellular signal transduction networks.<h4>Results</h4>We have generated lncRNA expression profiles from the CD34+ haematopoietic stem and progBioinformatics (Oxford, England)Annotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method.PMC5860060U01 CA166886R01 LM0101851R01GM123037U01 HL1115601U01HL111560613731051U01AR069395U01 AR0693951R01LM0101851U01CA166886R01 GM12303761672422Beck DLiu KLiu LThoms JAIZhao WPimanda JEZhou XfalseAnnotating function to differentially expressed LincRNAs in myelodysplastic syndrome using a network-based method.<h4>Motivation</h4>Long non-coding RNAs (lncRNAs) have been implicated in the regulation of diverse biological functions. The number of newly identified lncRNAs has increased dramatically in recent years but their expression and function have not yet been described from most diseases. To elucidate lncRNA function in human disease, we have developed a novel network based method (NLCFA) integrating correlations between lncRNA, protein coding genes and noncoding miRNAs. We have also integrated target gene associations and protein-protein interactions and designed our model to provide information on the combined influence of mRNAs, lncRNAs and miRNAs on cellular signal transduction networks.<h4>Results</h4>We have generated lncRNA expression profiles from the CD34+ haematopoietic stem and prog2017-01-01T00:00:00Z2017 Sep2026-05-01T16:19:56.833Z2019-03-26T23:53:16ZS-EPMC58600602847227110.1093/bioinformatics/btx280