biostudies-literatureXiao FNCATS NIH HHSNIDA NIH HHS2384-2385https://www.ebi.ac.uk/biostudies/studies/S-EPMC5860124biostudies-literatureUnknown33(15)Chromosomal copy number variation (CNV) refers to a polymorphism that a DNA segment presents deletion or duplication in the population. The computational algorithms developed to identify this type of variation are usually of high computational complexity. Here we present a user-friendly R package, modSaRa, designed to perform copy number variants identification. The package is developed based on a change-point based method with optimal computational complexity and desirable accuracy. The current version of modSaRa package is a comprehensive tool with integration of preprocessing steps and main CNV calling steps.modSaRa is an R package written in R, C?++?and Rcpp and is now freely available for download at http://c2s2.yale.edu/software/modSaRa .heping.zhang@yale.edu.Supplementary data are available at Bioinformatics online.Bioinformatics (Oxford, England)modSaRa: a computationally efficient R package for CNV identification.PMC5860124R01 DA016750UL1 TR001863Hao NZhang HXiao FJin ZNiu YXu YfalsemodSaRa: a computationally efficient R package for CNV identification.Chromosomal copy number variation (CNV) refers to a polymorphism that a DNA segment presents deletion or duplication in the population. The computational algorithms developed to identify this type of variation are usually of high computational complexity. Here we present a user-friendly R package, modSaRa, designed to perform copy number variants identification. The package is developed based on a change-point based method with optimal computational complexity and desirable accuracy. The current version of modSaRa package is a comprehensive tool with integration of preprocessing steps and main CNV calling steps.modSaRa is an R package written in R, C?++?and Rcpp and is now freely available for download at http://c2s2.yale.edu/software/modSaRa .heping.zhang@yale.edu.Supplementary data are available at Bioinformatics online.2017-01-01T00:00:00Z2017 Aug2021-02-20T12:14:36Z2019-03-26T23:48:52ZS-EPMC58601242845361110.1093/bioinformatics/btx212