{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bjornstad P"],"funding":["NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","JDRF"],"pagination":["831-839"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5860840"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(4)"],"pubmed_abstract":["OBJECTIVE:Central adiposity is considered to be an important cardiorenal risk factor in the general population and in type 1 diabetes. We sought to determine the relationship between central adiposity and intrarenal hemodynamic function in adults with long-standing type 1 diabetes with and without diabetic nephropathy (DN). RESEARCH DESIGN AND METHODS:Patients with type 1 diabetes (n = 66, duration ≥50 years) and age-/sex-matched control subjects (n = 73) were studied. The cohort was stratified into 44 DN Resistors (estimated glomerular filtration rate [eGFR] >60 mL/min/1.73 m2 and <30 mg/day urine albumin) and 22 patients with DN (eGFR ≤60 mL/min/1.73 m2 or ≥30 mg/day urine albumin). Intrarenal hemodynamic function (glomerular filtration rate for inulin [GFRINULIN], effective renal plasma"],"journal":["Diabetes care"],"pubmed_title":["Adiposity Impacts Intrarenal Hemodynamic Function in Adults With Long-standing Type 1 Diabetes With and Without Diabetic Nephropathy: Results From the Canadian Study of Longevity in Type 1 Diabetes."],"pmcid":["PMC5860840"],"funding_grant_id":["T32 DK063687","17-2013-312","K23 DK116720","T32-DK063687"],"pubmed_authors":["Tse J","Cham L","Alhuzaim ON","Paul N","Lovshin JA","Lytvyn Y","Farooqi MA","Brent MH","Weisman A","Boulet G","Orszag A","Scarr D","Cherney DZI","Lai V","Bjornstad P","Perkins BA","Lovblom LE","Keenan HA","Bril V"],"additional_accession":[]},"is_claimable":false,"name":"Adiposity Impacts Intrarenal Hemodynamic Function in Adults With Long-standing Type 1 Diabetes With and Without Diabetic Nephropathy: Results From the Canadian Study of Longevity in Type 1 Diabetes.","description":"OBJECTIVE:Central adiposity is considered to be an important cardiorenal risk factor in the general population and in type 1 diabetes. We sought to determine the relationship between central adiposity and intrarenal hemodynamic function in adults with long-standing type 1 diabetes with and without diabetic nephropathy (DN). RESEARCH DESIGN AND METHODS:Patients with type 1 diabetes (n = 66, duration ≥50 years) and age-/sex-matched control subjects (n = 73) were studied. The cohort was stratified into 44 DN Resistors (estimated glomerular filtration rate [eGFR] >60 mL/min/1.73 m2 and <30 mg/day urine albumin) and 22 patients with DN (eGFR ≤60 mL/min/1.73 m2 or ≥30 mg/day urine albumin). Intrarenal hemodynamic function (glomerular filtration rate for inulin [GFRINULIN], effective renal plasma","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2025-04-05T15:14:02.235Z","creation":"2019-06-06T19:09:55Z"},"accession":"S-EPMC5860840","cross_references":{"pubmed":["29437821"],"doi":["10.2337/dc17-2475"]}}