biostudies-literatureGordin DTom BeatsonNational Institute of Diabetes and Digestive and Kidney DiseasesIacocca Family FoundationNCRR NIH HHSLiv och Hälsa FoundationPäivikki and Sakari Sohlberg FoundationFinnish Medical FoundationJDRFBiomedicum Helsinki FoundationKarl Walter och Jarl Walter Perkléns FoundationJr 284 FoundationNovo NordiskNIDDK NIH HHSFolkhälsan Research FoundationWilhelm and Else Stockmann FoundationSwedish Cultural Foundation in FinlandMedical Society of FinlandDorothea OliviaEVO815-822https://www.ebi.ac.uk/biostudies/studies/S-EPMC5860842biostudies-literatureUnknown41(4)OBJECTIVE:Independent association of chronic kidney disease (CKD) and proliferative diabetic retinopathy (PDR) with cardiovascular disease (CVD) has not been established. In the Joslin 50-Year Medalist study, characterizing individuals with type 1 diabetes for 50 years or more, we examined the associations of CKD and PDR with CVD, which was validated by another cohort with type 1 diabetes from Finland. RESEARCH DESIGN AND METHODS:This cross-sectional study characterized U.S. residents (n = 762) with type 1 diabetes of 50 years or longer (Medalists) at a single site by questionnaire, clinical, ophthalmic, and laboratory studies. A replication cohort (n = 675) from the longitudinal Finnish Diabetic Nephropathy Study (FinnDiane) was used. CKD and PDR were defined as estimated glomerular filtrDiabetes careDifferential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes.PMC5860842R24 DK083957T32 DK00726017-2013-310P30-DK-036836UL1 RR025758R24-283-DK-083957-01DP3 DK094333UL1-RR-025758-03P30 DK036836DP3 DK112192T32-DK-007260DP3-DK-094333-01Groop PHGordin DForsblom CD'Eon SStillman IEPober DKhatri MTinsley LSun JKFickweiler WKing GLAmenta PSHarjutsalo VKeenan HAfalseDifferential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes.OBJECTIVE:Independent association of chronic kidney disease (CKD) and proliferative diabetic retinopathy (PDR) with cardiovascular disease (CVD) has not been established. In the Joslin 50-Year Medalist study, characterizing individuals with type 1 diabetes for 50 years or more, we examined the associations of CKD and PDR with CVD, which was validated by another cohort with type 1 diabetes from Finland. RESEARCH DESIGN AND METHODS:This cross-sectional study characterized U.S. residents (n = 762) with type 1 diabetes of 50 years or longer (Medalists) at a single site by questionnaire, clinical, ophthalmic, and laboratory studies. A replication cohort (n = 675) from the longitudinal Finnish Diabetic Nephropathy Study (FinnDiane) was used. CKD and PDR were defined as estimated glomerular filtr2018-01-01T00:00:00Z2018 Apr2025-04-05T15:14:05.124Z2019-06-06T19:10:01ZS-EPMC58608422938625010.2337/dc17-2250