{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rudolph MC"],"funding":["NICHD NIH HHS","NIDDK NIH HHS","NCI NIH HHS"],"pagination":["651-661"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5860857"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["67(4)"],"pubmed_abstract":["Adipose tissue expansion progresses rapidly during postnatal life, influenced by both prenatal maternal factors and postnatal developmental cues. The ratio of omega-6 (n-6) relative to n-3 polyunsaturated fatty acids (PUFAs) is believed to regulate perinatal adipogenesis, but the cellular mechanisms and long-term effects are not well understood. We lowered the fetal and postnatal n-6/n-3 PUFA ratio exposure in wild-type offspring under standard maternal dietary fat amounts to test the effects of low n-6/n-3 ratios on offspring adipogenesis and adipogenic potential. Relative to wild-type pups receiving high perinatal n-6/n-3 ratios, subcutaneous adipose tissue in 14-day-old wild-type pups receiving low n-6/n-3 ratios had more adipocytes that were smaller in size; decreased Pparγ2, Fabp4, an"],"journal":["Diabetes"],"pubmed_title":["Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance."],"pmcid":["PMC5860857"],"funding_grant_id":["P30 DK048520","P01 HD038129","P50 HD073063","R01 HD075285","R24 DK090964","T32 HD007186","R01 CA164166","K01 DK109079","K12 HD057022"],"pubmed_authors":["Webb PG","Houck JA","Yang IV","Friedman JE","Presby DM","de la Houssaye BA","Soderborg TK","Rudolph MC","Jackman MR","MacLean PS","Johnson GC"],"additional_accession":[]},"is_claimable":false,"name":"Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance.","description":"Adipose tissue expansion progresses rapidly during postnatal life, influenced by both prenatal maternal factors and postnatal developmental cues. The ratio of omega-6 (n-6) relative to n-3 polyunsaturated fatty acids (PUFAs) is believed to regulate perinatal adipogenesis, but the cellular mechanisms and long-term effects are not well understood. We lowered the fetal and postnatal n-6/n-3 PUFA ratio exposure in wild-type offspring under standard maternal dietary fat amounts to test the effects of low n-6/n-3 ratios on offspring adipogenesis and adipogenic potential. Relative to wild-type pups receiving high perinatal n-6/n-3 ratios, subcutaneous adipose tissue in 14-day-old wild-type pups receiving low n-6/n-3 ratios had more adipocytes that were smaller in size; decreased Pparγ2, Fabp4, an","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2026-06-07T06:47:11.895Z","creation":"2019-08-04T08:21:55Z"},"accession":"S-EPMC5860857","cross_references":{"pubmed":["29138256"],"doi":["10.2337/db17-0890"]}}