{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Adamson PD"],"funding":["British Heart Foundation","Medical Research Council","Chief Scientist Office","Health Research Board","Heart Diseases Research Fund","Edinburgh and Lothians Health Foundation","Wellcome Trust"],"pagination":["207-214"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5861384"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["104(3)"],"pubmed_abstract":["<h4>Objectives</h4>To evaluate the diagnostic and prognostic benefits of CT coronary angiography (CTCA) using the 2016 National Institute for Health and Care Excellence (NICE) guidelines for the assessment of suspected stable angina.<h4>Methods</h4>Post hoc analysis of the Scottish COmputed Tomography of the HEART (SCOT-HEART) trial of 4146 participants with suspected angina randomised to CTCA. Patients were dichotomised into NICE guideline-defined possible angina and non-anginal presentations. Primary (diagnostic) endpoint was diagnostic certainty of angina at 6 weeks and prognostic endpoint comprised fatal and non-fatal myocardial infarction (MI).<h4>Results</h4>In 3770 eligible participants, CTCA increased diagnostic certainty more in those with possible angina (relative risk (RR) 2.22 "],"journal":["Heart (British Cardiac Society)"],"pubmed_title":["Diagnostic and prognostic benefits of computed tomography coronary angiography using the 2016 National Institute for Health and Care Excellence guidance within a randomised trial."],"pmcid":["PMC5861384"],"funding_grant_id":["CH/09/002","G0701127","FS/11/014","103782/Z/14/Z","FS/16/14/32023","WT103782AIA","MR/N003403/1","FS/14/78/31020","RL-2013-11","FS/16/19/31982"],"pubmed_authors":["Flather M","van Beek EJR","Roditi G","Berry C","Clark E","Forbes J","Hunter A","McAllister DA","Boon NA","Newby DE","Adamson PD","Timmis AD","Shah ASV","Dweck MR","Williams MC","Mills NL","Pawade TA","McLean S"],"additional_accession":[]},"is_claimable":false,"name":"Diagnostic and prognostic benefits of computed tomography coronary angiography using the 2016 National Institute for Health and Care Excellence guidance within a randomised trial.","description":"<h4>Objectives</h4>To evaluate the diagnostic and prognostic benefits of CT coronary angiography (CTCA) using the 2016 National Institute for Health and Care Excellence (NICE) guidelines for the assessment of suspected stable angina.<h4>Methods</h4>Post hoc analysis of the Scottish COmputed Tomography of the HEART (SCOT-HEART) trial of 4146 participants with suspected angina randomised to CTCA. Patients were dichotomised into NICE guideline-defined possible angina and non-anginal presentations. Primary (diagnostic) endpoint was diagnostic certainty of angina at 6 weeks and prognostic endpoint comprised fatal and non-fatal myocardial infarction (MI).<h4>Results</h4>In 3770 eligible participants, CTCA increased diagnostic certainty more in those with possible angina (relative risk (RR) 2.22 ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Feb","modification":"2026-07-15T17:54:35.559Z","creation":"2019-03-26T22:43:35Z"},"accession":"S-EPMC5861384","cross_references":{"pubmed":["28844992"],"doi":["10.1136/heartjnl-2017-311508"]}}