biostudies-literatureAdamson PDBritish Heart FoundationMedical Research CouncilChief Scientist OfficeHealth Research BoardHeart Diseases Research FundEdinburgh and Lothians Health FoundationWellcome Trust207-214https://www.ebi.ac.uk/biostudies/studies/S-EPMC5861384biostudies-literatureUnknown104(3)<h4>Objectives</h4>To evaluate the diagnostic and prognostic benefits of CT coronary angiography (CTCA) using the 2016 National Institute for Health and Care Excellence (NICE) guidelines for the assessment of suspected stable angina.<h4>Methods</h4>Post hoc analysis of the Scottish COmputed Tomography of the HEART (SCOT-HEART) trial of 4146 participants with suspected angina randomised to CTCA. Patients were dichotomised into NICE guideline-defined possible angina and non-anginal presentations. Primary (diagnostic) endpoint was diagnostic certainty of angina at 6 weeks and prognostic endpoint comprised fatal and non-fatal myocardial infarction (MI).<h4>Results</h4>In 3770 eligible participants, CTCA increased diagnostic certainty more in those with possible angina (relative risk (RR) 2.22 Heart (British Cardiac Society)Diagnostic and prognostic benefits of computed tomography coronary angiography using the 2016 National Institute for Health and Care Excellence guidance within a randomised trial.PMC5861384CH/09/002G0701127FS/11/014103782/Z/14/ZFS/16/14/32023WT103782AIAMR/N003403/1FS/14/78/31020RL-2013-11FS/16/19/31982Flather Mvan Beek EJRRoditi GBerry CClark EForbes JHunter AMcAllister DABoon NANewby DEAdamson PDTimmis ADShah ASVDweck MRWilliams MCMills NLPawade TAMcLean SfalseDiagnostic and prognostic benefits of computed tomography coronary angiography using the 2016 National Institute for Health and Care Excellence guidance within a randomised trial.<h4>Objectives</h4>To evaluate the diagnostic and prognostic benefits of CT coronary angiography (CTCA) using the 2016 National Institute for Health and Care Excellence (NICE) guidelines for the assessment of suspected stable angina.<h4>Methods</h4>Post hoc analysis of the Scottish COmputed Tomography of the HEART (SCOT-HEART) trial of 4146 participants with suspected angina randomised to CTCA. Patients were dichotomised into NICE guideline-defined possible angina and non-anginal presentations. Primary (diagnostic) endpoint was diagnostic certainty of angina at 6 weeks and prognostic endpoint comprised fatal and non-fatal myocardial infarction (MI).<h4>Results</h4>In 3770 eligible participants, CTCA increased diagnostic certainty more in those with possible angina (relative risk (RR) 2.22 2018-01-01T00:00:00Z2018 Feb2026-07-15T17:54:35.559Z2019-03-26T22:43:35ZS-EPMC58613842884499210.1136/heartjnl-2017-311508