{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Egli A"],"funding":["Nachwuchsförderung","Swiss National Science Foundation"],"pagination":["51"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5861655"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["<h4>Background</h4>Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations?<h4>Methods</h4>Five hundred twenty eight patients were recruited in a prospective observational multicentre cohort (PROMISE) study. The genetic polymorphisms (rs8099917 and rs12979860) within the IFNL3/4 gene region and circulating levels of IFNL3 in COPD patients were determined and associated with disease activity and outcome during a median follow-up of 24 months.<h4>Results</h4>The GG genotype significantly influenced severe exacerbation rate (42 vs. 23%; p = 0.032) and time to severe exacerbation (HR = 2.260; p = 0.012). Compared to the TT or TG genotypes, the GG genotype was associated with severe dy"],"journal":["BMC pulmonary medicine"],"pubmed_title":["IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes."],"pmcid":["PMC5861655"],"funding_grant_id":["154709","PZ00P3_154709/1","128412","PP00P3_128412/1"],"pubmed_authors":["Blasi F","Roth M","Lacoma A","Thomas B","Mandal J","Stolz D","Boersma W","Schumann DM","Louis R","Kostikas K","Rentsch K","Aerts JG","Lorne Tyrrell D","Milenkovic B","Rohde GGU","Tamm M","Egli A","Welte T","Torres A"],"additional_accession":[]},"is_claimable":false,"name":"IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes.","description":"<h4>Background</h4>Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations?<h4>Methods</h4>Five hundred twenty eight patients were recruited in a prospective observational multicentre cohort (PROMISE) study. The genetic polymorphisms (rs8099917 and rs12979860) within the IFNL3/4 gene region and circulating levels of IFNL3 in COPD patients were determined and associated with disease activity and outcome during a median follow-up of 24 months.<h4>Results</h4>The GG genotype significantly influenced severe exacerbation rate (42 vs. 23%; p = 0.032) and time to severe exacerbation (HR = 2.260; p = 0.012). Compared to the TT or TG genotypes, the GG genotype was associated with severe dy","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2025-04-18T23:39:25.024Z","creation":"2019-06-06T19:10:11Z"},"accession":"S-EPMC5861655","cross_references":{"pubmed":["29562888"],"doi":["10.1186/s12890-018-0616-6"]}}