biostudies-literatureEgli ANachwuchsförderungSwiss National Science Foundation51https://www.ebi.ac.uk/biostudies/studies/S-EPMC5861655biostudies-literatureUnknown18(1)<h4>Background</h4>Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations?<h4>Methods</h4>Five hundred twenty eight patients were recruited in a prospective observational multicentre cohort (PROMISE) study. The genetic polymorphisms (rs8099917 and rs12979860) within the IFNL3/4 gene region and circulating levels of IFNL3 in COPD patients were determined and associated with disease activity and outcome during a median follow-up of 24 months.<h4>Results</h4>The GG genotype significantly influenced severe exacerbation rate (42 vs. 23%; p = 0.032) and time to severe exacerbation (HR = 2.260; p = 0.012). Compared to the TT or TG genotypes, the GG genotype was associated with severe dyBMC pulmonary medicineIFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes.PMC5861655154709PZ00P3_154709/1128412PP00P3_128412/1Blasi FRoth MLacoma AThomas BMandal JStolz DBoersma WSchumann DMLouis RKostikas KRentsch KAerts JGLorne Tyrrell DMilenkovic BRohde GGUTamm MEgli AWelte TTorres AfalseIFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes.<h4>Background</h4>Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations?<h4>Methods</h4>Five hundred twenty eight patients were recruited in a prospective observational multicentre cohort (PROMISE) study. The genetic polymorphisms (rs8099917 and rs12979860) within the IFNL3/4 gene region and circulating levels of IFNL3 in COPD patients were determined and associated with disease activity and outcome during a median follow-up of 24 months.<h4>Results</h4>The GG genotype significantly influenced severe exacerbation rate (42 vs. 23%; p = 0.032) and time to severe exacerbation (HR = 2.260; p = 0.012). Compared to the TT or TG genotypes, the GG genotype was associated with severe dy2018-01-01T00:00:00Z2018 Mar2025-04-18T23:39:25.024Z2019-06-06T19:10:11ZS-EPMC58616552956288810.1186/s12890-018-0616-6