{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Abidi SNF"],"funding":["NIH HHS","NIGMS NIH HHS"],"pagination":["4950"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5862905"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["The imaginal discs of the genetically tractable model organism Drosophila melanogaster have been used to study cell-fate specification and plasticity, including homeotic changes and regeneration-induced transdetermination. The identity of the reprogramming mechanisms that induce plasticity has been of great interest in the field. Here we identify a change from antennal fate to eye fate induced by a Distal-less-GAL4 (DllGAL4) P-element insertion that is a mutant allele of Dll and expresses GAL4 in the antennal imaginal disc. While this fate change is not induced by tissue damage, it appears to be a hybrid of transdetermination and homeosis as the GAL4 expression causes upregulation of Wingless, and the Dll mutation is required for the fate change. Neither GAL4 expression nor a Dll mutation "],"journal":["Scientific reports"],"pubmed_title":["Cell fate changes induced by a Distal-less enhancer-trap transgene in the Drosophila antennal imaginal disc."],"pmcid":["PMC5862905"],"funding_grant_id":["R01 GM107140","P40 OD018537"],"pubmed_authors":["Smith-Bolton RK","Abidi SNF"],"additional_accession":[]},"is_claimable":false,"name":"Cell fate changes induced by a Distal-less enhancer-trap transgene in the Drosophila antennal imaginal disc.","description":"The imaginal discs of the genetically tractable model organism Drosophila melanogaster have been used to study cell-fate specification and plasticity, including homeotic changes and regeneration-induced transdetermination. The identity of the reprogramming mechanisms that induce plasticity has been of great interest in the field. Here we identify a change from antennal fate to eye fate induced by a Distal-less-GAL4 (DllGAL4) P-element insertion that is a mutant allele of Dll and expresses GAL4 in the antennal imaginal disc. While this fate change is not induced by tissue damage, it appears to be a hybrid of transdetermination and homeosis as the GAL4 expression causes upregulation of Wingless, and the Dll mutation is required for the fate change. Neither GAL4 expression nor a Dll mutation ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2026-07-15T18:50:52.23Z","creation":"2019-03-26T23:20:35Z"},"accession":"S-EPMC5862905","cross_references":{"pubmed":["29563503"],"doi":["10.1038/s41598-018-23093-z"]}}