biostudies-literatureAbidi SNFNIH HHSNIGMS NIH HHS4950https://www.ebi.ac.uk/biostudies/studies/S-EPMC5862905biostudies-literatureUnknown8(1)The imaginal discs of the genetically tractable model organism Drosophila melanogaster have been used to study cell-fate specification and plasticity, including homeotic changes and regeneration-induced transdetermination. The identity of the reprogramming mechanisms that induce plasticity has been of great interest in the field. Here we identify a change from antennal fate to eye fate induced by a Distal-less-GAL4 (DllGAL4) P-element insertion that is a mutant allele of Dll and expresses GAL4 in the antennal imaginal disc. While this fate change is not induced by tissue damage, it appears to be a hybrid of transdetermination and homeosis as the GAL4 expression causes upregulation of Wingless, and the Dll mutation is required for the fate change. Neither GAL4 expression nor a Dll mutation Scientific reportsCell fate changes induced by a Distal-less enhancer-trap transgene in the Drosophila antennal imaginal disc.PMC5862905R01 GM107140P40 OD018537Smith-Bolton RKAbidi SNFfalseCell fate changes induced by a Distal-less enhancer-trap transgene in the Drosophila antennal imaginal disc.The imaginal discs of the genetically tractable model organism Drosophila melanogaster have been used to study cell-fate specification and plasticity, including homeotic changes and regeneration-induced transdetermination. The identity of the reprogramming mechanisms that induce plasticity has been of great interest in the field. Here we identify a change from antennal fate to eye fate induced by a Distal-less-GAL4 (DllGAL4) P-element insertion that is a mutant allele of Dll and expresses GAL4 in the antennal imaginal disc. While this fate change is not induced by tissue damage, it appears to be a hybrid of transdetermination and homeosis as the GAL4 expression causes upregulation of Wingless, and the Dll mutation is required for the fate change. Neither GAL4 expression nor a Dll mutation 2018-01-01T00:00:00Z2018 Mar2026-07-15T18:50:52.23Z2019-03-26T23:20:35ZS-EPMC58629052956350310.1038/s41598-018-23093-z