{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["103(4)"],"submitter":["Durr C"],"pubmed_abstract":["Chronic lymphocytic leukemia is a malignancy of mature B cells that strongly depend on microenvironmental factors, and their deprivation has been identified as a promising treatment approach for this incurable disease. Cytokine array screening of 247 chronic lymphocytic leukemia serum samples revealed elevated levels of tumor necrosis factor (TNF) receptor-1 which were associated with poor clinical outcome. We detected a microenvironment-induced expression of TNF receptor-1 in chronic lymphocytic leukemia cells in vitro, and an aberrantly high expression of this receptor in the proliferation centers of patients' lymph nodes. Stimulation of TNF receptor-1 with TNF-α enhanced nuclear factor κ-light-chain-enhancer of activated B cells (NFκB) activity and viability of chronic lymphocytic leuke"],"journal":["Haematologica"],"pagination":["688-697"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5865430"],"repository":["biostudies-literature"],"pubmed_title":["Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin."],"pmcid":["PMC5865430"],"pubmed_authors":["Zucknick M","Benner A","Gribben JG","Seiffert M","Clear A","Hanna BS","Schulz A","Krammer PH","Ohl S","Lichter P","Lucas F","Ozturk S","Durr C","Zenz T","Stilgenbauer S","Li-Weber M"],"additional_accession":[]},"is_claimable":false,"name":"Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin.","description":"Chronic lymphocytic leukemia is a malignancy of mature B cells that strongly depend on microenvironmental factors, and their deprivation has been identified as a promising treatment approach for this incurable disease. Cytokine array screening of 247 chronic lymphocytic leukemia serum samples revealed elevated levels of tumor necrosis factor (TNF) receptor-1 which were associated with poor clinical outcome. We detected a microenvironment-induced expression of TNF receptor-1 in chronic lymphocytic leukemia cells in vitro, and an aberrantly high expression of this receptor in the proliferation centers of patients' lymph nodes. Stimulation of TNF receptor-1 with TNF-α enhanced nuclear factor κ-light-chain-enhancer of activated B cells (NFκB) activity and viability of chronic lymphocytic leuke","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2025-04-04T12:55:14.909Z","creation":"2019-07-24T07:12:49Z"},"accession":"S-EPMC5865430","cross_references":{"pubmed":["29326123"],"doi":["10.3324/haematol.2017.177808"]}}