{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Patzelt T"],"funding":["Helmholtz-Gemeinschaft","Deutsche Forschungsgemeinschaft","European Research Council","Deutsche Krebshilfe"],"pagination":["3120-3125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5866538"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["115(12)"],"pubmed_abstract":["The transcription factor Foxp1 is critical for early B cell development. Despite frequent deregulation of Foxp1 in B cell lymphoma, the physiological functions of Foxp1 in mature B cells remain unknown. Here, we used conditional gene targeting in the B cell lineage and report that Foxp1 disruption in developing and mature B cells results in reduced numbers and frequencies of follicular and B-1 B cells and in impaired antibody production upon T cell-independent immunization in vivo. Moreover, <i>Foxp1</i>-deficient B cells are impaired in survival even though they exhibit an increased capacity to proliferate. Transcriptional analysis identified defective expression of the prosurvival Bcl-2 family gene <i>Bcl2l1</i> encoding Bcl-xl in Foxp1-deficient B cells, and we identified Foxp1 binding "],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells."],"pmcid":["PMC5866538"],"funding_grant_id":["SFB746","111026","ImmunoSensation","PCCC/WP8","EXC294","SFB1054/B01","70112036","RU 695/6-1","TRR130","322865","322972"],"pubmed_authors":["Patzelt T","Gorka O","Thoene S","Wartewig T","Reth M","Ruland J","Keppler SJ","Lang R","Buchner M","Forster I"],"additional_accession":[]},"is_claimable":false,"name":"Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells.","description":"The transcription factor Foxp1 is critical for early B cell development. Despite frequent deregulation of Foxp1 in B cell lymphoma, the physiological functions of Foxp1 in mature B cells remain unknown. Here, we used conditional gene targeting in the B cell lineage and report that Foxp1 disruption in developing and mature B cells results in reduced numbers and frequencies of follicular and B-1 B cells and in impaired antibody production upon T cell-independent immunization in vivo. Moreover, <i>Foxp1</i>-deficient B cells are impaired in survival even though they exhibit an increased capacity to proliferate. Transcriptional analysis identified defective expression of the prosurvival Bcl-2 family gene <i>Bcl2l1</i> encoding Bcl-xl in Foxp1-deficient B cells, and we identified Foxp1 binding ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2026-05-01T20:11:27.283Z","creation":"2019-03-26T23:47:20Z"},"accession":"S-EPMC5866538","cross_references":{"pubmed":["29507226"],"doi":["10.1073/pnas.1711335115"]}}