{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Dimitrakopoulos FD"],"pubmed_abstract":["During the last decade, a growing number of publications implicate NF-kB2 in NSCLC pathogenesis. Here, we investigated the clinical relevance of NF-kB2 single nucleotide polymorphisms (SNPs) rs7897947, rs11574852 and rs12769316 in NSCLC and their association with NF-kB2 protein and mRNA levels. Our data show that TT (rs7897947T >G) and AA (rs12769316G >A) genotypes were strongly associated with an increased risk for NSCLC (P = 0.019 and P = 0.003, respectively). Additionally, in multivariate analysis, TT (rs7897947T >G) homozygosity was associated with worse 2- and 3-year survival rates (P = 0.030 and P = 0.028, respectively), especially among patients with stages III/IV, who had worse 2, 3 and 5-year survival (P = 0.001, P = 0.022 and P = 0.035, respectively). In chemotherapy-treated pati"],"journal":["Scientific reports"],"pagination":["5259"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5869671"],"repository":["biostudies-literature"],"pubmed_title":["NF-kB2 Genetic Variations are Significantly Associated with Non-Small Cell Lung Cancer Risk and Overall Survival."],"pmcid":["PMC5869671"],"pubmed_authors":["Koukourikou I","Kalofonou M","Kottorou AE","Dougenis D","Makatsoris T","Maroussi S","Papadaki H","Koutras A","Kalofonos HP","Scopa C","Antonacopoulou AG","Panagopoulos N","Brock M","Dimitrakopoulos FD"],"additional_accession":[]},"is_claimable":false,"name":"NF-kB2 Genetic Variations are Significantly Associated with Non-Small Cell Lung Cancer Risk and Overall Survival.","description":"During the last decade, a growing number of publications implicate NF-kB2 in NSCLC pathogenesis. Here, we investigated the clinical relevance of NF-kB2 single nucleotide polymorphisms (SNPs) rs7897947, rs11574852 and rs12769316 in NSCLC and their association with NF-kB2 protein and mRNA levels. Our data show that TT (rs7897947T >G) and AA (rs12769316G >A) genotypes were strongly associated with an increased risk for NSCLC (P = 0.019 and P = 0.003, respectively). Additionally, in multivariate analysis, TT (rs7897947T >G) homozygosity was associated with worse 2- and 3-year survival rates (P = 0.030 and P = 0.028, respectively), especially among patients with stages III/IV, who had worse 2, 3 and 5-year survival (P = 0.001, P = 0.022 and P = 0.035, respectively). In chemotherapy-treated pati","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2026-04-29T15:41:08.45Z","creation":"2019-03-26T23:23:30Z"},"accession":"S-EPMC5869671","cross_references":{"pubmed":["29588475"],"doi":["10.1038/s41598-018-23324-3"]}}