{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Graziani V"],"pubmed_abstract":["The discovery of bioactive compounds from natural sources entails an extremely lengthy process due to the timescale and complexity of traditional methodologies. In our study, we used a rapid NMR based metabolomic approach as tool to identify secondary metabolites with anti-proliferative activity against a panel of human colorectal cancer cell lines with different mutation profiles. For this purpose, fourteen Fabaceae species of Mediterranean vegetation were investigated using a double screening method: <sup>1</sup>H NMR profiling enabled the identification of the main compounds present in the mixtures, whilst parallel biological assays allowed the selection of two plant extracts based on their strong anti-proliferative properties. Using high-resolution 2D NMR spectroscopy, putative active "],"journal":["Scientific reports"],"pagination":["5309"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5871890"],"repository":["biostudies-literature"],"pubmed_title":["Metabolomic approach for a rapid identification of natural products with cytotoxic activity against human colorectal cancer cells."],"pmcid":["PMC5871890"],"pubmed_authors":["Chambery A","Esposito A","D'Abrosca B","Belli V","Fiorentino A","Panella M","Potenza N","Russo R","Graziani V","Ciardiello F","Russo A","Troiani T","Scognamiglio M"],"additional_accession":[]},"is_claimable":false,"name":"Metabolomic approach for a rapid identification of natural products with cytotoxic activity against human colorectal cancer cells.","description":"The discovery of bioactive compounds from natural sources entails an extremely lengthy process due to the timescale and complexity of traditional methodologies. In our study, we used a rapid NMR based metabolomic approach as tool to identify secondary metabolites with anti-proliferative activity against a panel of human colorectal cancer cell lines with different mutation profiles. For this purpose, fourteen Fabaceae species of Mediterranean vegetation were investigated using a double screening method: <sup>1</sup>H NMR profiling enabled the identification of the main compounds present in the mixtures, whilst parallel biological assays allowed the selection of two plant extracts based on their strong anti-proliferative properties. Using high-resolution 2D NMR spectroscopy, putative active ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2026-05-05T23:10:00.023Z","creation":"2019-03-26T23:23:22Z"},"accession":"S-EPMC5871890","cross_references":{"pubmed":["29593231"],"doi":["10.1038/s41598-018-23704-9"]}}