biostudies-literaturePark YNICHD NIH HHSNIA NIH HHSNIMH NIH HHSk1218https://www.ebi.ac.uk/biostudies/studies/S-EPMC5871903biostudies-literatureUnknown360<h4>Objective</h4>To compare the risk of in-hospital mortality associated with haloperidol compared with atypical antipsychotics in patients admitted to hospital with acute myocardial infarction.<h4>Design</h4>Cohort study using a healthcare database.<h4>Setting</h4>Nationwide sample of patient data from more than 700 hospitals across the United States.<h4>Participants</h4>6578 medical patients aged more than 18 years who initiated oral haloperidol or oral atypical antipsychotics (olanzapine, quetiapine, risperidone) during a hospital admission with a primary diagnosis of acute myocardial infarction between 2003 and 2014.<h4>Main outcome measure</h4>In-hospital mortality during seven days of follow-up from treatment initiation.<h4>Results</h4>Among 6578 patients (mean age 75.2 years) treatBMJ (Clinical research ed.)Use of haloperidol versus atypical antipsychotics and risk of in-hospital death in patients with acute myocardial infarction: cohort study.PMC5871903K08 HD075831K01 MH099141K08 AG051187Kim DHPark YHuybrechts KFPatorno EHernandez-Diaz SMogun HGlynn RJBateman BTfalseUse of haloperidol versus atypical antipsychotics and risk of in-hospital death in patients with acute myocardial infarction: cohort study.<h4>Objective</h4>To compare the risk of in-hospital mortality associated with haloperidol compared with atypical antipsychotics in patients admitted to hospital with acute myocardial infarction.<h4>Design</h4>Cohort study using a healthcare database.<h4>Setting</h4>Nationwide sample of patient data from more than 700 hospitals across the United States.<h4>Participants</h4>6578 medical patients aged more than 18 years who initiated oral haloperidol or oral atypical antipsychotics (olanzapine, quetiapine, risperidone) during a hospital admission with a primary diagnosis of acute myocardial infarction between 2003 and 2014.<h4>Main outcome measure</h4>In-hospital mortality during seven days of follow-up from treatment initiation.<h4>Results</h4>Among 6578 patients (mean age 75.2 years) treat2018-01-01T00:00:00Z2018 Mar2025-04-26T06:50:32.243Z2019-03-26T23:20:55ZS-EPMC58719032959295810.1136/bmj.k1218