{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["128(4)"],"submitter":["Shimobayashi M"],"pubmed_abstract":["Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of proinflammatory macrophages and inflammation. However, the causal relationship of these events is unclear. Here, we report that obesity-induced insulin resistance in mice precedes macrophage accumulation and inflammation in adipose tissue. Using a mouse model that combines genetically induced, adipose-specific insulin resistance (mTORC2-knockout) and diet-induced obesity, we found that insulin resistance causes local accumulation of proinflammatory macrophages. Mechanistically, insulin resistance in adipocytes results in production of the chemokine monocyte chemoattractant protein 1 (MCP1), which recruits monocytes and activat"],"journal":["The Journal of clinical investigation"],"pagination":["1538-1550"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5873875"],"repository":["biostudies-literature"],"pubmed_title":["Insulin resistance causes inflammation in adipose tissue."],"pmcid":["PMC5873875"],"pubmed_authors":["Swierczynska MM","Hall MN","Jeno P","Peterli R","Clement N","Woelnerhanssen B","Albert V","Weissenberger D","Moes S","Frei IC","Colombi M","Meyer-Gerspach AC","Meier JA","Shimobayashi M","Beglinger C"],"additional_accession":[]},"is_claimable":false,"name":"Insulin resistance causes inflammation in adipose tissue.","description":"Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue, obesity-mediated insulin resistance correlates with the accumulation of proinflammatory macrophages and inflammation. However, the causal relationship of these events is unclear. Here, we report that obesity-induced insulin resistance in mice precedes macrophage accumulation and inflammation in adipose tissue. Using a mouse model that combines genetically induced, adipose-specific insulin resistance (mTORC2-knockout) and diet-induced obesity, we found that insulin resistance causes local accumulation of proinflammatory macrophages. Mechanistically, insulin resistance in adipocytes results in production of the chemokine monocyte chemoattractant protein 1 (MCP1), which recruits monocytes and activat","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2025-04-26T03:39:10.015Z","creation":"2019-03-26T23:44:12Z"},"accession":"S-EPMC5873875","cross_references":{"pubmed":["29528335"],"doi":["10.1172/jci96139","10.1172/JCI96139"]}}