{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ghose P"],"funding":["NICHD NIH HHS","NCI NIH HHS","NINDS NIH HHS","NIGMS NIH HHS","NIH HHS"],"pagination":["393-399"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5876135"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(4)"],"pubmed_abstract":["Phagocytosis of dying cells is critical in development and immunity<sup>1-3</sup>. Although proteins for recognition and engulfment of cellular debris following cell death are known<sup>4,5</sup>, proteins that directly mediate phagosome sealing are uncharacterized. Furthermore, whether all phagocytic targets are cleared using the same machinery is unclear. Degeneration of morphologically complex cells, such as neurons, glia and melanocytes, produces phagocytic targets of various shapes and sizes located in different microenvironments<sup>6,7</sup>. Thus, such cells offer unique settings to explore engulfment programme mechanisms and specificity. Here, we report that dismantling and clearance of a morphologically complex Caenorhabditis elegans epithelial cell requires separate cell soma, p"],"journal":["Nature cell biology"],"pubmed_title":["EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans."],"pmcid":["PMC5876135"],"funding_grant_id":["R35 NS105094","R01 GM097576","P30 CA008748","R35 GM142489","F32 HD089640","R01 HD078703","P40 OD010440","R01 NS081490","R24 OD016474"],"pubmed_authors":["Insley P","Ghose P","Rashid A","Shah P","Bao Z","Singhal A","Lu Y","Shaham S","Trivedi M"],"additional_accession":[]},"is_claimable":false,"name":"EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans.","description":"Phagocytosis of dying cells is critical in development and immunity<sup>1-3</sup>. Although proteins for recognition and engulfment of cellular debris following cell death are known<sup>4,5</sup>, proteins that directly mediate phagosome sealing are uncharacterized. Furthermore, whether all phagocytic targets are cleared using the same machinery is unclear. Degeneration of morphologically complex cells, such as neurons, glia and melanocytes, produces phagocytic targets of various shapes and sizes located in different microenvironments<sup>6,7</sup>. Thus, such cells offer unique settings to explore engulfment programme mechanisms and specificity. Here, we report that dismantling and clearance of a morphologically complex Caenorhabditis elegans epithelial cell requires separate cell soma, p","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2025-04-04T21:17:40.915Z","creation":"2019-03-26T23:56:19Z"},"accession":"S-EPMC5876135","cross_references":{"pubmed":["29556089"],"doi":["10.1038/s41556-018-0068-5"]}}