{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Sheen JM"],"pubmed_abstract":["This study aimed to study the impact of a combination of maternal and post-weaning high-fat diets and whether resveratrol was beneficial. Sprague-Dawley dams were fed either chow or a high-fat diet, before mating, during pregnancy, and into lactation. At weaning, their offspring were randomly fed chow or a high-fat diet. Four experimental groups were generated: CC (maternal/postnatal chow diet), HC (maternal high-fat/postnatal chow diet), CH (maternal chow/postnatal high-fat diet), and HH (maternal/postnatal high-fat diet). A fifth group consisted of HH plus resveratrol. The 4 month-old offspring of HH group had higher body weight, higher levels of plasma triglycerides, leptin, angiotensin I and angiotensin II and abnormal intraperitoneal glucose tolerance test results, which fulfilled the"],"journal":["Scientific reports"],"pagination":["5607"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5884801"],"repository":["biostudies-literature"],"pubmed_title":["Combined maternal and postnatal high-fat diet leads to metabolic syndrome and is effectively reversed by resveratrol: a multiple-organ study."],"pmcid":["PMC5884801"],"pubmed_authors":["Tsai WL","Lin IC","Yu HR","Tsai CC","Tain YL","Lin YJ","Huang LT","Sheen JM","Tiao MM"],"additional_accession":[]},"is_claimable":false,"name":"Combined maternal and postnatal high-fat diet leads to metabolic syndrome and is effectively reversed by resveratrol: a multiple-organ study.","description":"This study aimed to study the impact of a combination of maternal and post-weaning high-fat diets and whether resveratrol was beneficial. Sprague-Dawley dams were fed either chow or a high-fat diet, before mating, during pregnancy, and into lactation. At weaning, their offspring were randomly fed chow or a high-fat diet. Four experimental groups were generated: CC (maternal/postnatal chow diet), HC (maternal high-fat/postnatal chow diet), CH (maternal chow/postnatal high-fat diet), and HH (maternal/postnatal high-fat diet). A fifth group consisted of HH plus resveratrol. The 4 month-old offspring of HH group had higher body weight, higher levels of plasma triglycerides, leptin, angiotensin I and angiotensin II and abnormal intraperitoneal glucose tolerance test results, which fulfilled the","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2025-04-21T19:58:19.645Z","creation":"2019-03-26T23:27:57Z"},"accession":"S-EPMC5884801","cross_references":{"pubmed":["29618822"],"doi":["10.1038/s41598-018-24010-0"]}}