{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["75(5)"],"submitter":["Rosenbohm A"],"pubmed_abstract":["Importance:Knowledge about the metabolic states of patients with amyotrophic lateral sclerosis (ALS) may provide a therapeutic approach. Objective:To investigate the association between the onset and prognosis of ALS and serum retinol-binding protein 4 (RBP4) concentration as a biomarker for insulin resistance and vitamin A metabolism. Design, Setting, and Participants:Case-control design for risk factors of ALS; cohort design for prognostic factors within ALS cases. Between October 1, 2010, and June 30, 2014, a population-based case-control study with randomly selected controls was established based on the ALS Registry Swabia in southern Germany, with a target population of 8.4 million inhabitants. Response rates were 64.8% among the cases and 18.7% among the controls. The dates of analys"],"journal":["JAMA neurology"],"pagination":["600-607"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5885207"],"repository":["biostudies-literature"],"pubmed_title":["Association of Serum Retinol-Binding Protein 4 Concentration With Risk for and Prognosis of Amyotrophic Lateral Sclerosis."],"pmcid":["PMC5885207"],"pubmed_authors":["Schuetz K","Raape J","Schmauss M","Weiler M","Rothenbacher D","Hendrich C","Nagel G","Brehme T","Dupuis L","Asshauer I","Huber R","Schlipf T","Heimbach B","Hacke W","Metrikat J","Wessig C","Bengel D","Etzersdorfer E","Baezner H","Beattie J","Schweigert B","Synofzik M","Peter RS","Freund W","Dieterich M","Hecht M","Behne F","Ratzka P","Baier H","Kern R","Kuethmann A","Opherk C","Huber-Hartmann K","Boertlein A","Juttler E","Neuhaus O","Kaspar A","Naegele A","Broer R","Dempewolf S","Sommer N","Rettenmayr C","Lindner A","Schoels L","Klopstock T","Lewis D","Meyer A","Tumani H","Steber","Steber R","Maier-Janson W","Meudt O","Klebe S","Arnold G","Becker T","Herting B","Hulser P","Hamann G","Ludolph AC","Schabet M","Alber B","Muller vom Hagen J","Sabolek M","Schell C","Hemmer B","Lule D","Kammerer-Ciernioch J","Rothmeier J","Andres F","Gold H","Stroick M","Neher K","Gersner T","Koenig W","Neusch C","ALS Registry Study Group","Winkler A","Bracknies V","Weber F","Naumann M","Wahl C","Lichy C","Rosenbohm A","Kimmig H","Kohler A","Connemann B","Trottenberg T","Weiller C","Kloetzsch C","Sperber W","Dettmers C","Maurer M","Riepe M"],"additional_accession":[]},"is_claimable":false,"name":"Association of Serum Retinol-Binding Protein 4 Concentration With Risk for and Prognosis of Amyotrophic Lateral Sclerosis.","description":"Importance:Knowledge about the metabolic states of patients with amyotrophic lateral sclerosis (ALS) may provide a therapeutic approach. Objective:To investigate the association between the onset and prognosis of ALS and serum retinol-binding protein 4 (RBP4) concentration as a biomarker for insulin resistance and vitamin A metabolism. Design, Setting, and Participants:Case-control design for risk factors of ALS; cohort design for prognostic factors within ALS cases. Between October 1, 2010, and June 30, 2014, a population-based case-control study with randomly selected controls was established based on the ALS Registry Swabia in southern Germany, with a target population of 8.4 million inhabitants. Response rates were 64.8% among the cases and 18.7% among the controls. The dates of analys","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2025-04-21T19:57:42.734Z","creation":"2019-08-03T07:23:20Z"},"accession":"S-EPMC5885207","cross_references":{"pubmed":["29482216"],"doi":["10.1001/jamaneurol.2017.5129"]}}