biostudies-literatureUnknown75(5)Rosenbohm AImportance:Knowledge about the metabolic states of patients with amyotrophic lateral sclerosis (ALS) may provide a therapeutic approach. Objective:To investigate the association between the onset and prognosis of ALS and serum retinol-binding protein 4 (RBP4) concentration as a biomarker for insulin resistance and vitamin A metabolism. Design, Setting, and Participants:Case-control design for risk factors of ALS; cohort design for prognostic factors within ALS cases. Between October 1, 2010, and June 30, 2014, a population-based case-control study with randomly selected controls was established based on the ALS Registry Swabia in southern Germany, with a target population of 8.4 million inhabitants. Response rates were 64.8% among the cases and 18.7% among the controls. The dates of analysJAMA neurology600-607https://www.ebi.ac.uk/biostudies/studies/S-EPMC5885207biostudies-literatureAssociation of Serum Retinol-Binding Protein 4 Concentration With Risk for and Prognosis of Amyotrophic Lateral Sclerosis.PMC5885207Schuetz KRaape JSchmauss MWeiler MRothenbacher DHendrich CNagel GBrehme TDupuis LAsshauer IHuber RSchlipf THeimbach BHacke WMetrikat JWessig CBengel DEtzersdorfer EBaezner HBeattie JSchweigert BSynofzik MPeter RSFreund WDieterich MHecht MBehne FRatzka PBaier HKern RKuethmann AOpherk CHuber-Hartmann KBoertlein AJuttler ENeuhaus OKaspar ANaegele ABroer RDempewolf SSommer NRettenmayr CLindner ASchoels LKlopstock TLewis DMeyer ATumani HSteberSteber RMaier-Janson WMeudt OKlebe SArnold GBecker THerting BHulser PHamann GLudolph ACSchabet MAlber BMuller vom Hagen JSabolek MSchell CHemmer BLule DKammerer-Ciernioch JRothmeier JAndres FGold HStroick MNeher KGersner TKoenig WNeusch CALS Registry Study GroupWinkler ABracknies VWeber FNaumann MWahl CLichy CRosenbohm AKimmig HKohler AConnemann BTrottenberg TWeiller CKloetzsch CSperber WDettmers CMaurer MRiepe MfalseAssociation of Serum Retinol-Binding Protein 4 Concentration With Risk for and Prognosis of Amyotrophic Lateral Sclerosis.Importance:Knowledge about the metabolic states of patients with amyotrophic lateral sclerosis (ALS) may provide a therapeutic approach. Objective:To investigate the association between the onset and prognosis of ALS and serum retinol-binding protein 4 (RBP4) concentration as a biomarker for insulin resistance and vitamin A metabolism. Design, Setting, and Participants:Case-control design for risk factors of ALS; cohort design for prognostic factors within ALS cases. Between October 1, 2010, and June 30, 2014, a population-based case-control study with randomly selected controls was established based on the ALS Registry Swabia in southern Germany, with a target population of 8.4 million inhabitants. Response rates were 64.8% among the cases and 18.7% among the controls. The dates of analys2018-01-01T00:00:00Z2018 May2025-04-21T19:57:42.734Z2019-08-03T07:23:20ZS-EPMC58852072948221610.1001/jamaneurol.2017.5129