{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mullins RF"],"funding":["NEI NIH HHS","Department of Health"],"pagination":["R51-R57"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5886463"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(R1)"],"pubmed_abstract":["Age-related macular degeneration (AMD) is a major cause of visual impairment that affects the central retina. Genome wide association studies and candidate gene screens have identified members of the complement pathway as contributing to the risk of AMD. In this review, we discuss the complement system, its importance in retinal development and normal physiology, how its dysregulation may contribute to disease, and how it might be targeted to prevent damage to the aging choriocapillaris in AMD."],"journal":["Human molecular genetics"],"pubmed_title":["From compliment to insult: genetics of the complement system in physiology and disease in the human retina."],"pmcid":["PMC5886463"],"funding_grant_id":["P30 EY025580","R01 EY026547","NF-SI-0515-10020","R01 EY024605"],"pubmed_authors":["Mullins RF","Lotery AJ","Sohn EH","Warwick AN"],"additional_accession":[]},"is_claimable":false,"name":"From compliment to insult: genetics of the complement system in physiology and disease in the human retina.","description":"Age-related macular degeneration (AMD) is a major cause of visual impairment that affects the central retina. Genome wide association studies and candidate gene screens have identified members of the complement pathway as contributing to the risk of AMD. In this review, we discuss the complement system, its importance in retinal development and normal physiology, how its dysregulation may contribute to disease, and how it might be targeted to prevent damage to the aging choriocapillaris in AMD.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2021-02-20T08:32:39Z","creation":"2019-03-26T23:48:52Z"},"accession":"S-EPMC5886463","cross_references":{"pubmed":["28482029"],"doi":["10.1093/hmg/ddx181"]}}