{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["60(2)"],"submitter":["Afroz T"],"pubmed_abstract":["OBJECTIVES:Indium compounds are used in manufacturing displays of mobile phones and televisions. However, these materials cause interstitial pneumonia in exposed workers. Animal experiments demonstrated that indium compounds caused lung cancer. Chronic inflammation is considered to play a role in lung carcinogenesis and fibrosis induced by particulate matters. 8-Nitroguanine (8-nitroG) is a mutagenic DNA lesion formed during inflammation and may participate in carcinogenesis. To clarify the mechanism of carcinogenesis, we examined 8-nitroG formation in indium-exposed cultured cells. METHODS:We treated RAW 264.7 mouse macrophages with indium oxide (In2O3) nanoparticles (primary diameter: 30-50 nm), and performed fluorescent immunocytochemistry to detect 8-nitroG. The extent of 8-nitroG form"],"journal":["Journal of occupational health"],"pagination":["148-155"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5886882"],"repository":["biostudies-literature"],"pubmed_title":["Nitrative DNA damage in cultured macrophages exposed to indium oxide."],"pmcid":["PMC5886882"],"pubmed_authors":["Afroz T","Ahmed S","Ma N","Hiraku Y","Murata M","Kawanishi S","Oikawa S"],"additional_accession":[]},"is_claimable":false,"name":"Nitrative DNA damage in cultured macrophages exposed to indium oxide.","description":"OBJECTIVES:Indium compounds are used in manufacturing displays of mobile phones and televisions. However, these materials cause interstitial pneumonia in exposed workers. Animal experiments demonstrated that indium compounds caused lung cancer. Chronic inflammation is considered to play a role in lung carcinogenesis and fibrosis induced by particulate matters. 8-Nitroguanine (8-nitroG) is a mutagenic DNA lesion formed during inflammation and may participate in carcinogenesis. To clarify the mechanism of carcinogenesis, we examined 8-nitroG formation in indium-exposed cultured cells. METHODS:We treated RAW 264.7 mouse macrophages with indium oxide (In2O3) nanoparticles (primary diameter: 30-50 nm), and performed fluorescent immunocytochemistry to detect 8-nitroG. The extent of 8-nitroG form","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2025-04-19T08:57:21.451Z","creation":"2019-03-26T23:27:59Z"},"accession":"S-EPMC5886882","cross_references":{"pubmed":["29187674"],"doi":["10.1539/joh.17-0146-OA"]}}