{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wong C"],"funding":["Ontario Ministry of Health and Long Term Care","NICHD NIH HHS","NCATS NIH HHS","NIDA NIH HHS","NCRR NIH HHS","NIA NIH HHS","NIAID NIH HHS","NIAAA NIH HHS","Health Resources and Services Administration","Canadian Institutes of Health Research","CIHR","NEI NIH HHS","Agency for Healthcare Research and Quality","NIMHD NIH HHS","National Cancer Institute","NCI NIH HHS"],"pagination":["1230-1238"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5889007"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["66(8)"],"pubmed_abstract":["<h4>Background</h4>Age-associated conditions are increasingly common among persons living with human immunodeficiency virus (HIV) (PLWH). A longitudinal investigation of their accrual is needed given their implications on clinical care complexity. We examined trends in the co-occurrence of age-associated conditions among PLWH receiving clinical care, and differences in their prevalence by demographic subgroup.<h4>Methods</h4>This cohort study was nested within the North American AIDS Cohort Collaboration on Research and Design. Participants from HIV outpatient clinics were antiretroviral therapy-exposed PLWH receiving clinical care (ie, ≥1 CD4 count) in the United States during 2000-2009. Multimorbidity was irreversible, defined as having ≥2: hypertension, diabetes mellitus, chronic kidney disease, hypercholesterolemia, end-stage liver disease, or non-AIDS-related cancer. Adjusted prevalence ratios (aPR) and 95% confidence intervals (CIs) comparing demographic subgroups were obtained by Poisson regression with robust error variance, using generalized estimating equations for repeated measures.<h4>Results</h4>Among 22969 adults, 79% were male, 36% were black, and the median baseline age was 40 years (interquartile range, 34-46 years). Between 2000 and 2009, multimorbidity prevalence increased from 8.2% to 22.4% (Ptrend < .001). Adjusting for age, this trend was still significant (P < .001). There was no difference by sex, but blacks were less likely than whites to have multimorbidity (aPR, 0.87; 95% CI, .77-.99). Multimorbidity was the highest among heterosexuals, relative to men who have sex with men (aPR, 1.16; 95% CI, 1.01-1.34). Hypertension and hypercholesterolemia most commonly co-occurred.<h4>Conclusions</h4>Multimorbidity prevalence has increased among PLWH. Comorbidity prevention and multisubspecialty management of increasingly complex healthcare needs will be vital to ensuring that they receive needed care."],"journal":["Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"],"pubmed_title":["Multimorbidity Among Persons Living with Human Immunodeficiency Virus in the United States."],"pmcid":["PMC5889007"],"funding_grant_id":["K01 AI131895","K24 DA000432","U01 AI038858","U01 AI038855","KL2 TR000421","R01 DA011602","U01 AI068636","R01 AA016893","U01 AA020790","U01 AI103401","U01 AI103408","UL1 TR000083","U01 AI068634","K23 EY013707","U10 EY008067","P30 AI027767","TGF-96118","CBR-94036","P30 AI027763","U01 AI031834","U01 AI034989","HCP-97105","U01 AI037613","U01 AI103397","P30 AI036219","U01 HD032632","UM1 AI035043","UL1 TR000004","U01 AI035039","U24 AA020794","U01 AI103390","U01 AI042590","M01 RR000052","R01 CA165937","P30 AI050410","K01 AI093197","U10 EY008057","P30 AI027757","U01 AA013566","P30 AI110527","UL1 TR000454","U01 AI034994","F31 DA037788","U01 AI034993","U01 AI035004","U10 EY008052","U01 AI037984","U01 AI035041","U01 AI035040","G12 MD007583","U01 AI035042","R24 AG044325","UL1 RR024131","P30 AI094189","R24 AI067039","U01 DA036935","K24 AI065298","R01 AG053100","90051652","CBR-86906","R01 DA012568","90047713","U01 AI069918","U54 MD007587","Z01 CP010176","U01 AI069432","K24 AI118591","U01 AI069434"],"pubmed_authors":["Gebo KA","Klein MB","Rabkin CS","Saag MS","Hunter-Mellado RF","Sterling TR","Mugavero MJ","Globerman J","Haas D","Patel P","Eron JJ","Anastos K","Gange SJ","Kitahata MM","Harrigan PR","Moore RD","Boswell S","Benson CA","Koethe JR","Justice AC","Mayor A","Crane HM","North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD)","Bosch RJ","Palella FJ","Martin JN","Rachlis AR","Althoff KN","Abraham AG","Cescon A","Rourke SB","Samji H","Fiellin D","Buchacz K","Mayer KH","Hogg RS","Montaner JS","Drozd DR","Kopansky-Giles M","Boyd CM","Rodriguez B","Gabler K","Wong C","Gill MJ","McKaig RG","Thorne J","Turner M","Willig J","Bebawy S","Silverberg MJ","Rogers B","Dubrow R","Jacobson LP","Napravnik S","Kirk GD","Rebeiro PF","Brooks JT","Grasso C","Horberg MA","Freeman AM"],"additional_accession":[]},"is_claimable":false,"name":"Multimorbidity Among Persons Living with Human Immunodeficiency Virus in the United States.","description":"<h4>Background</h4>Age-associated conditions are increasingly common among persons living with human immunodeficiency virus (HIV) (PLWH). A longitudinal investigation of their accrual is needed given their implications on clinical care complexity. We examined trends in the co-occurrence of age-associated conditions among PLWH receiving clinical care, and differences in their prevalence by demographic subgroup.<h4>Methods</h4>This cohort study was nested within the North American AIDS Cohort Collaboration on Research and Design. Participants from HIV outpatient clinics were antiretroviral therapy-exposed PLWH receiving clinical care (ie, ≥1 CD4 count) in the United States during 2000-2009. Multimorbidity was irreversible, defined as having ≥2: hypertension, diabetes mellitus, chronic kidney disease, hypercholesterolemia, end-stage liver disease, or non-AIDS-related cancer. Adjusted prevalence ratios (aPR) and 95% confidence intervals (CIs) comparing demographic subgroups were obtained by Poisson regression with robust error variance, using generalized estimating equations for repeated measures.<h4>Results</h4>Among 22969 adults, 79% were male, 36% were black, and the median baseline age was 40 years (interquartile range, 34-46 years). Between 2000 and 2009, multimorbidity prevalence increased from 8.2% to 22.4% (Ptrend < .001). Adjusting for age, this trend was still significant (P < .001). There was no difference by sex, but blacks were less likely than whites to have multimorbidity (aPR, 0.87; 95% CI, .77-.99). Multimorbidity was the highest among heterosexuals, relative to men who have sex with men (aPR, 1.16; 95% CI, 1.01-1.34). Hypertension and hypercholesterolemia most commonly co-occurred.<h4>Conclusions</h4>Multimorbidity prevalence has increased among PLWH. Comorbidity prevention and multisubspecialty management of increasingly complex healthcare needs will be vital to ensuring that they receive needed care.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2025-04-26T18:15:13.558Z","creation":"2019-08-04T07:30:23Z"},"accession":"S-EPMC5889007","cross_references":{"pubmed":["29149237"],"doi":["10.1093/cid/cix998"]}}