{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Moodie LWK"],"funding":["Norges Forskningsråd","VINNOVA"],"pagination":["257-267"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5889410"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(2)"],"pubmed_abstract":["By combining the recently reported repelling natural dihydrostilbene scaffold with an oxime moiety found in many marine antifoulants, a library of nine antifouling hybrid compounds was developed and biologically evaluated. The prepared compounds were shown to display a low antifouling effect against marine bacteria but a high potency against the attachment and growth of microalgae down to MIC values of 0.01 μg/mL for the most potent hybrid. The mode of action can be characterized as repelling via a reversible non-toxic biostatic mechanism. Barnacle cyprid larval settlement was also inhibited at low μg/mL concentrations with low levels or no toxicity observed. Several of the prepared compounds performed better than many reported antifouling marine natural products. While several of the prep"],"journal":["Marine biotechnology (New York, N.Y.)"],"pubmed_title":["Design and Biological Evaluation of Antifouling Dihydrostilbene Oxime Hybrids."],"pmcid":["PMC5889410"],"funding_grant_id":["ES508288","2014-01435"],"pubmed_authors":["Labriere C","Moodie LWK","Pavia H","Svenson J","Cervin G","Trepos R","Hellio C"],"additional_accession":[]},"is_claimable":false,"name":"Design and Biological Evaluation of Antifouling Dihydrostilbene Oxime Hybrids.","description":"By combining the recently reported repelling natural dihydrostilbene scaffold with an oxime moiety found in many marine antifoulants, a library of nine antifouling hybrid compounds was developed and biologically evaluated. The prepared compounds were shown to display a low antifouling effect against marine bacteria but a high potency against the attachment and growth of microalgae down to MIC values of 0.01 μg/mL for the most potent hybrid. The mode of action can be characterized as repelling via a reversible non-toxic biostatic mechanism. Barnacle cyprid larval settlement was also inhibited at low μg/mL concentrations with low levels or no toxicity observed. Several of the prepared compounds performed better than many reported antifouling marine natural products. While several of the prep","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2026-05-30T01:53:32.063Z","creation":"2019-03-26T23:29:20Z"},"accession":"S-EPMC5889410","cross_references":{"pubmed":["29532333"],"doi":["10.1007/s10126-018-9802-z"]}}