biostudies-literatureMoodie LWKNorges ForskningsrådVINNOVA257-267https://www.ebi.ac.uk/biostudies/studies/S-EPMC5889410biostudies-literatureUnknown20(2)By combining the recently reported repelling natural dihydrostilbene scaffold with an oxime moiety found in many marine antifoulants, a library of nine antifouling hybrid compounds was developed and biologically evaluated. The prepared compounds were shown to display a low antifouling effect against marine bacteria but a high potency against the attachment and growth of microalgae down to MIC values of 0.01 μg/mL for the most potent hybrid. The mode of action can be characterized as repelling via a reversible non-toxic biostatic mechanism. Barnacle cyprid larval settlement was also inhibited at low μg/mL concentrations with low levels or no toxicity observed. Several of the prepared compounds performed better than many reported antifouling marine natural products. While several of the prepMarine biotechnology (New York, N.Y.)Design and Biological Evaluation of Antifouling Dihydrostilbene Oxime Hybrids.PMC5889410ES5082882014-01435Labriere CMoodie LWKPavia HSvenson JCervin GTrepos RHellio CfalseDesign and Biological Evaluation of Antifouling Dihydrostilbene Oxime Hybrids.By combining the recently reported repelling natural dihydrostilbene scaffold with an oxime moiety found in many marine antifoulants, a library of nine antifouling hybrid compounds was developed and biologically evaluated. The prepared compounds were shown to display a low antifouling effect against marine bacteria but a high potency against the attachment and growth of microalgae down to MIC values of 0.01 μg/mL for the most potent hybrid. The mode of action can be characterized as repelling via a reversible non-toxic biostatic mechanism. Barnacle cyprid larval settlement was also inhibited at low μg/mL concentrations with low levels or no toxicity observed. Several of the prepared compounds performed better than many reported antifouling marine natural products. While several of the prep2018-01-01T00:00:00Z2018 Apr2026-05-30T01:53:32.063Z2019-03-26T23:29:20ZS-EPMC58894102953233310.1007/s10126-018-9802-z