{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Carlton EW"],"funding":["Royal College of Emergency Medicine","Emergency Care Foundation, New Zealand","Queensland Emergency Medicine Research Foundation","National Institute for Health Research (NIHR)","Canterbury Medical Research Foundation"],"pagination":["665-672"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5890641"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["104(8)"],"pubmed_abstract":["<h4>Objective</h4>We aimed to evaluate the limit of detection of high-sensitivity troponin (hs-cTn) and Thrombolysis In Myocardial Infarction (TIMI) score combination rule-out strategy suggested within the 2016 National Institute for Health and Care Excellence (NICE) Chest Pain of Recent Onset guidelines and establish the optimal TIMI score threshold for clinical use.<h4>Methods</h4>A pooled analysis of adult patients presenting to the emergency department with chest pain and a non-ischaemic ECG, recruited into six prospective studies, from Australia, New Zealand and the UK. We evaluated the sensitivity of TIMI score thresholds from 0 to 2 alongside hs-cTnT or hs-cTnI for the primary outcome of major adverse cardiac events within 30 days.<h4>Results</h4>Data were available for 3159 patient"],"journal":["Heart (British Cardiac Society)"],"pubmed_title":["Assessment of the 2016 National Institute for Health and Care Excellence high-sensitivity troponin rule-out strategy."],"pmcid":["PMC5890641"],"funding_grant_id":["PDF-2012-05-193"],"pubmed_authors":["Pickering JW","Than M","Parsonage WA","Greaves K","Cullen L","Khattab A","Greenslade J","Kendall J","Carlton EW","Body R"],"additional_accession":[]},"is_claimable":false,"name":"Assessment of the 2016 National Institute for Health and Care Excellence high-sensitivity troponin rule-out strategy.","description":"<h4>Objective</h4>We aimed to evaluate the limit of detection of high-sensitivity troponin (hs-cTn) and Thrombolysis In Myocardial Infarction (TIMI) score combination rule-out strategy suggested within the 2016 National Institute for Health and Care Excellence (NICE) Chest Pain of Recent Onset guidelines and establish the optimal TIMI score threshold for clinical use.<h4>Methods</h4>A pooled analysis of adult patients presenting to the emergency department with chest pain and a non-ischaemic ECG, recruited into six prospective studies, from Australia, New Zealand and the UK. We evaluated the sensitivity of TIMI score thresholds from 0 to 2 alongside hs-cTnT or hs-cTnI for the primary outcome of major adverse cardiac events within 30 days.<h4>Results</h4>Data were available for 3159 patient","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2026-07-15T21:27:49.896Z","creation":"2026-07-09T10:14:24.305Z"},"accession":"S-EPMC5890641","cross_references":{"pubmed":["28864718"],"doi":["10.1136/heartjnl-2017-311983"]}}