biostudies-literatureCarlton EWRoyal College of Emergency MedicineEmergency Care Foundation, New ZealandQueensland Emergency Medicine Research FoundationNational Institute for Health Research (NIHR)Canterbury Medical Research Foundation665-672https://www.ebi.ac.uk/biostudies/studies/S-EPMC5890641biostudies-literatureUnknown104(8)<h4>Objective</h4>We aimed to evaluate the limit of detection of high-sensitivity troponin (hs-cTn) and Thrombolysis In Myocardial Infarction (TIMI) score combination rule-out strategy suggested within the 2016 National Institute for Health and Care Excellence (NICE) Chest Pain of Recent Onset guidelines and establish the optimal TIMI score threshold for clinical use.<h4>Methods</h4>A pooled analysis of adult patients presenting to the emergency department with chest pain and a non-ischaemic ECG, recruited into six prospective studies, from Australia, New Zealand and the UK. We evaluated the sensitivity of TIMI score thresholds from 0 to 2 alongside hs-cTnT or hs-cTnI for the primary outcome of major adverse cardiac events within 30 days.<h4>Results</h4>Data were available for 3159 patientHeart (British Cardiac Society)Assessment of the 2016 National Institute for Health and Care Excellence high-sensitivity troponin rule-out strategy.PMC5890641PDF-2012-05-193Pickering JWThan MParsonage WAGreaves KCullen LKhattab AGreenslade JKendall JCarlton EWBody RfalseAssessment of the 2016 National Institute for Health and Care Excellence high-sensitivity troponin rule-out strategy.<h4>Objective</h4>We aimed to evaluate the limit of detection of high-sensitivity troponin (hs-cTn) and Thrombolysis In Myocardial Infarction (TIMI) score combination rule-out strategy suggested within the 2016 National Institute for Health and Care Excellence (NICE) Chest Pain of Recent Onset guidelines and establish the optimal TIMI score threshold for clinical use.<h4>Methods</h4>A pooled analysis of adult patients presenting to the emergency department with chest pain and a non-ischaemic ECG, recruited into six prospective studies, from Australia, New Zealand and the UK. We evaluated the sensitivity of TIMI score thresholds from 0 to 2 alongside hs-cTnT or hs-cTnI for the primary outcome of major adverse cardiac events within 30 days.<h4>Results</h4>Data were available for 3159 patient2018-01-01T00:00:00Z2018 Apr2026-07-15T21:27:49.896Z2026-07-09T10:14:24.305ZS-EPMC58906412886471810.1136/heartjnl-2017-311983