{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(1)"],"submitter":["Naidoo DB"],"funding":["Department of Science and Technology, Government of India","Manipal University","National Research Foundation","South African Medical Research Council"],"pubmed_abstract":["<h4>Background</h4>Cancer and inflammation are associated with cachexia. Withania somnifera (W. somnifera) possesses antioxidant and anti-inflammatory potential. We investigated the potential of an aqueous extract of the root of W. somnifera (W<sub>RE</sub>) to modulate cytokines, antioxidants and apoptosis in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC's).<h4>Methods</h4>Cytotoxcity of W<sub>RE</sub> was determined at 24 and 72 h (h). Oxidant scavenging activity of W<sub>RE</sub> was evaluated (2, 2-diphenyl-1 picrylhydrazyl assay). Glutathione (GSH) levels, caspase (- 8, - 9, - 3/7) activities and adenosine triphosphate (ATP) levels (Luminometry) were thereafter assayed. Tumour necrosis factor-α (TNF-α), interleukin (IL)-6, IL-1β and IL-10 levels were also assessed"],"journal":["BMC complementary and alternative medicine"],"pagination":["126"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5891897"],"repository":["biostudies-literature"],"pubmed_title":["Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC's)."],"pmcid":["PMC5891897"],"pubmed_authors":["Chuturgoon AA","Satyamoorthy K","Sewram V","Guruprasad KP","Naidoo DB","Phulukdaree A"],"additional_accession":[]},"is_claimable":false,"name":"Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC's).","description":"<h4>Background</h4>Cancer and inflammation are associated with cachexia. Withania somnifera (W. somnifera) possesses antioxidant and anti-inflammatory potential. We investigated the potential of an aqueous extract of the root of W. somnifera (W<sub>RE</sub>) to modulate cytokines, antioxidants and apoptosis in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC's).<h4>Methods</h4>Cytotoxcity of W<sub>RE</sub> was determined at 24 and 72 h (h). Oxidant scavenging activity of W<sub>RE</sub> was evaluated (2, 2-diphenyl-1 picrylhydrazyl assay). Glutathione (GSH) levels, caspase (- 8, - 9, - 3/7) activities and adenosine triphosphate (ATP) levels (Luminometry) were thereafter assayed. Tumour necrosis factor-α (TNF-α), interleukin (IL)-6, IL-1β and IL-10 levels were also assessed","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2025-04-18T19:48:58.42Z","creation":"2019-03-26T23:29:24Z"},"accession":"S-EPMC5891897","cross_references":{"pubmed":["29631586"],"doi":["10.1186/s12906-018-2192-y"]}}