{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou K"],"funding":["Chinese Academy of Sciences","Fundamental Research Funds for the Central Universities","National Natural Science Foundation of China"],"pagination":["236-244"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5894109"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(Pt 4)"],"pubmed_abstract":["Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional enzyme that plays critical roles in bacterial pathogenesis in some pathogenic bacteria. In this study, the crystal structure of group B streptococcus GAPDH was determined at 1.36 Å resolution. The structure contained an asymmetric mixed holo tetramer, with two NAD ligands bound to two protomers. Further structural analysis identified interesting phosphate ion-binding sites, which shed light on its catalytic mechanism."],"journal":["Acta crystallographica. Section F, Structural biology communications"],"pubmed_title":["High-resolution crystal structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase."],"pmcid":["PMC5894109"],"funding_grant_id":["U1732109"],"pubmed_authors":["Li Y","Fan X","Jin T","Zhang C","Zhou K"],"additional_accession":[]},"is_claimable":false,"name":"High-resolution crystal structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase.","description":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional enzyme that plays critical roles in bacterial pathogenesis in some pathogenic bacteria. In this study, the crystal structure of group B streptococcus GAPDH was determined at 1.36 Å resolution. The structure contained an asymmetric mixed holo tetramer, with two NAD ligands bound to two protomers. Further structural analysis identified interesting phosphate ion-binding sites, which shed light on its catalytic mechanism.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2025-04-19T00:29:09.385Z","creation":"2020-05-22T14:54:33Z"},"accession":"S-EPMC5894109","cross_references":{"pubmed":["29633972"],"doi":["10.1107/s2053230x18003801","10.1107/S2053230X18003801"]}}