{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kishimoto D"],"funding":["Yokohama Foundation for Advanced Medical Science","Naito Foundation","Japanese Society for the Promotion of Science Grants-in-Aid for Scientific Research","Takeda Medical Research Foundation","Japan Agency for Medical Research and Development","Japan Intractable Diseases Research Foundation","Japan Rheumatic Disease Foundation","Uehara Memorial Foundation","Mochida Memorial Foundation for Medical and Pharmaceutical Research","Japan Society for the Promotion of Science"],"pagination":["64"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5894134"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["BACKGROUND:Innate immunity including macrophages (Mϕ) in lupus nephritis (LN) has been gaining attention, but roles of Mϕ in LN remain uncertain. METHODS:Immunohistochemical staining was performed to determine CD68, CD163, heme oxygenase (HO)-1 (a stress-inducible heme-degrading enzyme with anti-inflammatory property), pSTAT1, and CMAF-expressing Mϕ in the glomeruli of patients with LN. Effects of type I interferons on the expression levels of CD163, HO-1, BTB and CNC homology 1 (Bach1; a transcriptional HO-1 repressor), interleukin (IL)-6, and IL-10 by human M2-like Mϕ, which were differentiated in vitro from peripheral monocytes with macrophage colony-stimulating factor, were assessed by RT-PCR and immunocytostaining. Clinical manifestations, anti-double-stranded DNA (anti-dsDNA), and lo"],"journal":["Arthritis research & therapy"],"pubmed_title":["Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons."],"pmcid":["PMC5894134"],"funding_grant_id":["26860756","16K08698","7790011965","26461469","26461468","26713136"],"pubmed_authors":["Nagahama K","Yoshimi R","Nakajima H","Kunishita Y","Kirino Y","Nakano H","Aoki I","Takeno M","Takase-Minegishi K","Kishimoto D","Igarashi K","Kato I","Tamura M"],"additional_accession":[]},"is_claimable":false,"name":"Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons.","description":"BACKGROUND:Innate immunity including macrophages (Mϕ) in lupus nephritis (LN) has been gaining attention, but roles of Mϕ in LN remain uncertain. METHODS:Immunohistochemical staining was performed to determine CD68, CD163, heme oxygenase (HO)-1 (a stress-inducible heme-degrading enzyme with anti-inflammatory property), pSTAT1, and CMAF-expressing Mϕ in the glomeruli of patients with LN. Effects of type I interferons on the expression levels of CD163, HO-1, BTB and CNC homology 1 (Bach1; a transcriptional HO-1 repressor), interleukin (IL)-6, and IL-10 by human M2-like Mϕ, which were differentiated in vitro from peripheral monocytes with macrophage colony-stimulating factor, were assessed by RT-PCR and immunocytostaining. Clinical manifestations, anti-double-stranded DNA (anti-dsDNA), and lo","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2025-04-26T06:58:46.54Z","creation":"2019-03-26T23:29:29Z"},"accession":"S-EPMC5894134","cross_references":{"pubmed":["29636091"],"doi":["10.1186/s13075-018-1568-1"]}}