{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(1)"],"submitter":["Dursun G"],"pubmed_abstract":["<h4>Objective</h4>Behçet's disease (BD), a chronic multisystem inflammatory disorder, is mainly characterized by relapsing periods of a wide range of clinical symptoms. Several cytokine genes may play important roles in the pathogenesis of BD. Therefore, interleukin-1 receptor antagonist (IL-1Ra) gene 86bp variable number tandem repeat (VNTR) variant was investigated in patients with BD in a Turkish population.<h4>Methods</h4>One hundred nine patients (60 females, 49 males; the mean age±standard deviation [SD] was 36.56±9.571 years) with BD and one hundred healthy individuals (54 females, 46 males; the mean age±SD was 36.64±2.294 years) were examined in the study. For genotyping, polymerase chain reaction-restriction fragment length polymorphism analysis was employed. Data were analyzed us"],"journal":["European journal of rheumatology"],"pagination":["27-31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5895147"],"repository":["biostudies-literature"],"pubmed_title":["Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behcet's disease."],"pmcid":["PMC5895147"],"pubmed_authors":["Yigit S","Demir HD","Demir O","Karakus N","Nursal AF","Dursun G"],"additional_accession":[]},"is_claimable":false,"name":"Investigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behcet's disease.","description":"<h4>Objective</h4>Behçet's disease (BD), a chronic multisystem inflammatory disorder, is mainly characterized by relapsing periods of a wide range of clinical symptoms. Several cytokine genes may play important roles in the pathogenesis of BD. Therefore, interleukin-1 receptor antagonist (IL-1Ra) gene 86bp variable number tandem repeat (VNTR) variant was investigated in patients with BD in a Turkish population.<h4>Methods</h4>One hundred nine patients (60 females, 49 males; the mean age±standard deviation [SD] was 36.56±9.571 years) with BD and one hundred healthy individuals (54 females, 46 males; the mean age±SD was 36.64±2.294 years) were examined in the study. For genotyping, polymerase chain reaction-restriction fragment length polymorphism analysis was employed. Data were analyzed us","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Mar","modification":"2025-04-04T09:10:35.064Z","creation":"2019-03-26T23:47:53Z"},"accession":"S-EPMC5895147","cross_references":{"pubmed":["29657871"],"doi":["10.5152/eurjrheum.2017.16102"]}}