biostudies-literatureUnknown5(1)Dursun G<h4>Objective</h4>Behçet's disease (BD), a chronic multisystem inflammatory disorder, is mainly characterized by relapsing periods of a wide range of clinical symptoms. Several cytokine genes may play important roles in the pathogenesis of BD. Therefore, interleukin-1 receptor antagonist (IL-1Ra) gene 86bp variable number tandem repeat (VNTR) variant was investigated in patients with BD in a Turkish population.<h4>Methods</h4>One hundred nine patients (60 females, 49 males; the mean age±standard deviation [SD] was 36.56±9.571 years) with BD and one hundred healthy individuals (54 females, 46 males; the mean age±SD was 36.64±2.294 years) were examined in the study. For genotyping, polymerase chain reaction-restriction fragment length polymorphism analysis was employed. Data were analyzed usEuropean journal of rheumatology27-31https://www.ebi.ac.uk/biostudies/studies/S-EPMC5895147biostudies-literatureInvestigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behcet's disease.PMC5895147Yigit SDemir HDDemir OKarakus NNursal AFDursun GfalseInvestigation of the role of interleukin-1 receptor antagonist VNTR variant on the Behcet's disease.<h4>Objective</h4>Behçet's disease (BD), a chronic multisystem inflammatory disorder, is mainly characterized by relapsing periods of a wide range of clinical symptoms. Several cytokine genes may play important roles in the pathogenesis of BD. Therefore, interleukin-1 receptor antagonist (IL-1Ra) gene 86bp variable number tandem repeat (VNTR) variant was investigated in patients with BD in a Turkish population.<h4>Methods</h4>One hundred nine patients (60 females, 49 males; the mean age±standard deviation [SD] was 36.56±9.571 years) with BD and one hundred healthy individuals (54 females, 46 males; the mean age±SD was 36.64±2.294 years) were examined in the study. For genotyping, polymerase chain reaction-restriction fragment length polymorphism analysis was employed. Data were analyzed us2018-01-01T00:00:00Z2018 Mar2025-04-04T09:10:35.064Z2019-03-26T23:47:53ZS-EPMC58951472965787110.5152/eurjrheum.2017.16102