{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Lozovaya N"],"pubmed_abstract":["We report that half striatal cholinergic interneurons are dual transmitter cholinergic and GABAergic interneurons (CGINs) expressing ChAT, GAD65, Lhx7, and Lhx6 mRNAs, labeled with GAD and VGAT, generating monosynaptic dual cholinergic/GABAergic currents and an inhibitory pause response. Dopamine deprivation increases CGINs ongoing activity and abolishes GABAergic inhibition including the cortico-striatal pause because of high [Cl-]i levels. Dopamine deprivation also dramatically increases CGINs dendritic arbors and monosynaptic interconnections probability, suggesting the formation of a dense CGINs network. The NKCC1 chloride importer antagonist bumetanide, which reduces [Cl-]i levels, restores GABAergic inhibition, the cortico-striatal pause-rebound response, and attenuates motor effects"],"journal":["Nature communications"],"pagination":["1422"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5897332"],"repository":["biostudies-literature"],"pubmed_title":["GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease."],"pmcid":["PMC5897332"],"pubmed_authors":["Cloarec R","Riffault B","Dufour A","Burnashev N","Eftekhari S","Pons-Bennaceur A","Ben-Ari Y","Oumar N","Hammond C","Billon-Grand M","Gouty-Colomer LA","Lozovaya N"],"additional_accession":[]},"is_claimable":false,"name":"GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.","description":"We report that half striatal cholinergic interneurons are dual transmitter cholinergic and GABAergic interneurons (CGINs) expressing ChAT, GAD65, Lhx7, and Lhx6 mRNAs, labeled with GAD and VGAT, generating monosynaptic dual cholinergic/GABAergic currents and an inhibitory pause response. Dopamine deprivation increases CGINs ongoing activity and abolishes GABAergic inhibition including the cortico-striatal pause because of high [Cl-]i levels. Dopamine deprivation also dramatically increases CGINs dendritic arbors and monosynaptic interconnections probability, suggesting the formation of a dense CGINs network. The NKCC1 chloride importer antagonist bumetanide, which reduces [Cl-]i levels, restores GABAergic inhibition, the cortico-striatal pause-rebound response, and attenuates motor effects","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2025-04-18T18:22:06.591Z","creation":"2019-03-26T23:29:35Z"},"accession":"S-EPMC5897332","cross_references":{"pubmed":["29651049"],"doi":["10.1038/s41467-018-03802-y"]}}