{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(8)"],"submitter":["Griffiths RJ"],"funding":["GlaxoSmithKline"],"pubmed_abstract":["A transition metal-free strategy for the dehydrogenative β-sulfonylation of tertiary cyclic amines is described. N-Iodosuccinimide facilitates regioselective oxidative sulfonylation at C-H bonds positioned β to the nitrogen atom of tertiary amines, installing enaminyl sulfone functionality in cyclic systems. Mild reaction conditions, broad functional group tolerance and a wide substrate scope are demonstrated. The nucleophilic character of the enaminyl sulfone is harnessed, demonstrating potential application for scaffold diversification."],"journal":["Chemical science"],"pagination":["2295-2300"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5897885"],"repository":["biostudies-literature"],"pubmed_title":["Oxidative β-C-H sulfonylation of cyclic amines."],"pmcid":["PMC5897885"],"pubmed_authors":["Griffiths RJ","Kong WC","Talbot EPA","Richards SA","Burley GA","Willis MC"],"additional_accession":[]},"is_claimable":false,"name":"Oxidative β-C-H sulfonylation of cyclic amines.","description":"A transition metal-free strategy for the dehydrogenative β-sulfonylation of tertiary cyclic amines is described. N-Iodosuccinimide facilitates regioselective oxidative sulfonylation at C-H bonds positioned β to the nitrogen atom of tertiary amines, installing enaminyl sulfone functionality in cyclic systems. Mild reaction conditions, broad functional group tolerance and a wide substrate scope are demonstrated. The nucleophilic character of the enaminyl sulfone is harnessed, demonstrating potential application for scaffold diversification.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Feb","modification":"2025-04-04T13:34:26.192Z","creation":"2019-03-26T23:36:06Z"},"accession":"S-EPMC5897885","cross_references":{"pubmed":["29719703"],"doi":["10.1039/c7sc04900e"]}}