{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Delgado-Calle J"],"funding":["BLRD VA","NHLBI NIH HHS","National Institutes of Health","NIAMS NIH HHS","U.S. Department of Veterans Affairs"],"pagination":["2878-2890"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5901377"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(5)"],"pubmed_abstract":["Parathyroid hormone (PTH) affects the skeleton by acting on osteocytes (Ots) in bone through yet unclear mechanisms. We report that matrix metalloproteinase 14 (MMP14) expression/activity are increased in bones from mice with genetic constitutive activation (ca) of the PTH receptor 1 (PTH1R) in Ots (caPTH1ROt) and in bones from mice exposed to elevated PTH levels but not in mice lacking [conditional knockout (cKO)] the PTH1R in Ots (cKOPTH1ROt). Furthermore, PTH upregulates MMP14 in human bone cultures and in Ot-enriched bones from floxed control mice but not from cKOPTH1ROt mice. MMP14 activity increases soluble receptor activator of NF-κΒ ligand production, which in turn, stimulates osteoclast differentiation and resorption. Pharmacologic inhibition of MMP14 activity reduced the high bon"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production."],"pmcid":["PMC5901377"],"funding_grant_id":["R01 AR059357","I01 BX002104","1 101 BX002104‐01","T35 HL110854","R01‐AR060332","R01‐AR059357","R01 AR060332"],"pubmed_authors":["Sanudo C","Hancock B","Riancho JA","Tonra JR","Delgado-Calle J","McAndrews K","Bellido T","Bruzzaniti A","Likine EF","Sato AY"],"additional_accession":[]},"is_claimable":false,"name":"MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production.","description":"Parathyroid hormone (PTH) affects the skeleton by acting on osteocytes (Ots) in bone through yet unclear mechanisms. We report that matrix metalloproteinase 14 (MMP14) expression/activity are increased in bones from mice with genetic constitutive activation (ca) of the PTH receptor 1 (PTH1R) in Ots (caPTH1ROt) and in bones from mice exposed to elevated PTH levels but not in mice lacking [conditional knockout (cKO)] the PTH1R in Ots (cKOPTH1ROt). Furthermore, PTH upregulates MMP14 in human bone cultures and in Ot-enriched bones from floxed control mice but not from cKOPTH1ROt mice. MMP14 activity increases soluble receptor activator of NF-κΒ ligand production, which in turn, stimulates osteoclast differentiation and resorption. Pharmacologic inhibition of MMP14 activity reduced the high bon","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2025-05-29T22:17:38.326Z","creation":"2025-05-29T22:17:38.326Z"},"accession":"S-EPMC5901377","cross_references":{"pubmed":["29401593"],"doi":["10.1096/fj.201700919RRR","10.1096/fj.201700919rrr"]}}