{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wei S"],"funding":["the National Natural Science Foundation of China"],"pagination":["112"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5901872"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["<h4>Background</h4>The recombinant <i>Saccharomyces cerevisiae</i> strains that acquired the ability to utilize xylose through metabolic and evolutionary engineering exhibit good performance when xylose is the sole carbon source in the medium (designated the X stage in the present work). However, the xylose consumption rate of strains is generally low after glucose depletion during glucose-xylose co-fermentation, despite the presence of xylose in the medium (designated the GX stage in the present work). Glucose fermentation appears to reduce the capacity of these strains to \"recognize\" xylose during the GX stage, a phenomenon termed the post-glucose effect on xylose metabolism.<h4>Results</h4>Two independent xylose-fermenting <i>S. cerevisiae</i> strains derived from a haploid laboratory s"],"journal":["Biotechnology for biofuels"],"pubmed_title":["Disruption of the transcription factors Thi2p and Nrm1p alleviates the post-glucose effect on xylose utilization in <i>Saccharomyces cerevisiae</i>."],"pmcid":["PMC5901872"],"funding_grant_id":["31470166","31770046","31270151"],"pubmed_authors":["Liu Y","Wu M","Hou J","Wei S","Bao X","Ma T","Shen Y","Bai X"],"additional_accession":[]},"is_claimable":false,"name":"Disruption of the transcription factors Thi2p and Nrm1p alleviates the post-glucose effect on xylose utilization in <i>Saccharomyces cerevisiae</i>.","description":"<h4>Background</h4>The recombinant <i>Saccharomyces cerevisiae</i> strains that acquired the ability to utilize xylose through metabolic and evolutionary engineering exhibit good performance when xylose is the sole carbon source in the medium (designated the X stage in the present work). However, the xylose consumption rate of strains is generally low after glucose depletion during glucose-xylose co-fermentation, despite the presence of xylose in the medium (designated the GX stage in the present work). Glucose fermentation appears to reduce the capacity of these strains to \"recognize\" xylose during the GX stage, a phenomenon termed the post-glucose effect on xylose metabolism.<h4>Results</h4>Two independent xylose-fermenting <i>S. cerevisiae</i> strains derived from a haploid laboratory s","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2026-04-13T07:37:13.224Z","creation":"2019-03-26T23:31:33Z"},"accession":"S-EPMC5901872","cross_references":{"pubmed":["29686730"],"doi":["10.1186/s13068-018-1112-1"]}}