{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Verginelli F"],"funding":["Associazione Italiana per la Ricerca sul Cancro","Ministero dell’Istruzione, dell’Università e della Ricerca","NCI NIH HHS"],"pagination":["779-798"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5904229"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["135(5)"],"pubmed_abstract":["Tumours can be viewed as aberrant tissues or organs sustained by tumorigenic stem-like cells that engage into dysregulated histo/organogenetic processes. Paragangliomas, prototypical organoid tumours constituted by dysmorphic variants of the vascular and neural tissues found in normal paraganglia, provide a model to test this hypothesis. To understand the origin of paragangliomas, we built a biobank comprising 77 cases, 18 primary cultures, 4 derived cell lines, 80 patient-derived xenografts and 11 cell-derived xenografts. We comparatively investigated these unique complementary materials using morphofunctional, ultrastructural and flow cytometric assays accompanied by microRNA studies. We found that paragangliomas contain stem-like cells with hybrid mesenchymal/vasculoneural phenotype, st"],"journal":["Acta neuropathologica"],"pubmed_title":["Paragangliomas arise through an autonomous vasculo-angio-neurogenic program inhibited by imatinib."],"pmcid":["PMC5904229"],"funding_grant_id":["2015B7M39T","P30 CA008748","IG9168","IG16932"],"pubmed_authors":["Guarnieri S","Marchisio M","Opocher G","Veronese A","Soderberg-Naucler C","Sanna M","Sheu A","Rajasekhar VK","Tramontana L","Vespa S","Rossi C","Verginelli F","Bologna G","Paties CT","Morgano A","Cama A","Schiavi F","Esposito DL","Lanuti P","D'Argenio A","Pantalone MR","Florio R","Lotti LV","Taschin E","Visone R","Mariani-Costantini R","Perconti S","Prasad SC"],"additional_accession":[]},"is_claimable":false,"name":"Paragangliomas arise through an autonomous vasculo-angio-neurogenic program inhibited by imatinib.","description":"Tumours can be viewed as aberrant tissues or organs sustained by tumorigenic stem-like cells that engage into dysregulated histo/organogenetic processes. Paragangliomas, prototypical organoid tumours constituted by dysmorphic variants of the vascular and neural tissues found in normal paraganglia, provide a model to test this hypothesis. To understand the origin of paragangliomas, we built a biobank comprising 77 cases, 18 primary cultures, 4 derived cell lines, 80 patient-derived xenografts and 11 cell-derived xenografts. We comparatively investigated these unique complementary materials using morphofunctional, ultrastructural and flow cytometric assays accompanied by microRNA studies. We found that paragangliomas contain stem-like cells with hybrid mesenchymal/vasculoneural phenotype, st","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2025-04-04T10:09:57.214Z","creation":"2019-03-26T23:31:41Z"},"accession":"S-EPMC5904229","cross_references":{"pubmed":["29305721"],"doi":["10.1007/s00401-017-1799-2"]}}